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Thaís da Rocha Boeira,Janaina Coser,Jonas Michel Wolf,Bruna Klahr Manggini Cardinal,Ivana Grivicich,Daniel Simon,Vagner Ricardo Lunge 대한암예방학회 2018 Journal of cancer prevention Vol.23 No.3
Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression ofan HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 andRPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North Americanpopulations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited forthis study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model(C/C + C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated withCC protection (adjustedOR = 0.49; 95% CI: 0.27-0.90). However, the other polymorphisms evaluated did not present significant differencesbetween cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These resultssuggest a potential role of the RPS19 gene in CC.
Freitas Leandro Mendes,Antunes Flavia Tasmin Techera,Obach Eliane Sempe,Correa Aurea Pandolfo,Wiiland Elenir,de Mello Feliciano Liciane,Reinicke Adriana,Amado Gabriela Jouglard Vasquez,Grivicich Ivana 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.2
Purpose The pharmaceutical industry has been searching for drugs that aim at the prevention, the protection, and the recovery of the skin. Thus, the aim of this study was to evaluate the anti-inflammatory and anti-edematogenic activities of a topical emulsion containing Helianthus annuus oil (5%), glycerin (30%), and vitamin B3 (5%). Methods The aim was verified through chronic inflammatory responses and edema that were induced by irritant croton oil in the ears of mice, followed by histological and leukocyte infiltration. The study also affirmed the stability and the cytotoxicity of the emulsion. Results A stable, homogeneous, shiny, slightly-white, and gelatinous emulsion was obtained. The cytotoxicity evaluation allowed for the verification that only in high concentrations were unsatisfactory results presented. The treatment was effective in reversing the inflammatory parameters that were induced by croton oil, such as edema, neutrophil migration, and cell hyperproliferation. Conclusion The developed emulsion containing sunflower oil, glycerin, and vitamin B3 had parameters of stability and presented anti-inflammatory activities. The researchers’ findings suggest that the topical use of this formulation is a new and novel strategy for the treatment of inflammatory conditions of the skin.