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RISS 인기검색어
- 검색키워드
- 저자 : Indrakumar, S. (검색결과 2 건)
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Cai, L.,Indrakumar, S.,Kiarie, E.,Kim, I. H. Oxford University Press 2015 Journal of Animal Science Vol.93 No.9
<P>This experiment was conducted to investigate the effect of a spp.-based direct-fed microbial (DFM) on growth performance, apparent total tract digestibility (ATTD), blood profile, intestinal histomorphology, and fecal gas emission in piglets fed corn and soybean meal-based diets. The DFM product was based on 1 strain of and 2 strains of and formulated to supply 1.5 ?? 10 cfu/g of feed. A total of 128 piglets ([Yorkshire ?? Landrace] ?? Duroc; 6.8 ± 0.6 kg BW; weaning age: 24 d) were housed in groups (4 pigs/pen, 2 barrows and 2 gilts) and fed diets ( = 16) without or with DFM in a 2-phase feeding program: d 0 to 14 (phase I) and 15 to 42 (phase II). Feed intake and BW were measured weekly. At the end of each phase, samples for blood urea nitrogen (BUN), blood creatinine, ATTD, and fecal noxious gas emission were taken. At termination, 12 piglets per treatment were killed to access intestinal tissues for histomorphology. Overall, pigs fed DFM had a greater ( < 0.05) G:F than pigs fed the control diet. In phase I, pigs fed DFM showed a greater ( < 0.05) ADG and lower ( < 0.05) concentration of BUN and fecal ammonia emission than the control group. In phase II, a greater ( < 0.05) ATTD of nitrogen and longer ( < 0.05) duodenum and jejunum villi were observed in pigs fed the DFM diet compared with the control group. In conclusion, inclusion of DFM improved growth performance and villi length of the duodenum and jejunum in nursery pigs. Furthermore, DFM enhanced protein utilization as demonstrated by increased nitrogen digestibility, lower BUN, and lower fecal ammonia release.</P>
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Ane Nishitha Vijayan,Janani Indrakumar,Sankaranarayanan Gomathinayagam,Kodiveri Muthukaliannan Gothandam,Purna Sai Korrapati 한국고분자학회 2022 Macromolecular Research Vol.30 No.8
The blood-brain barrier (BBB) curtails the permeability of neuroprotective drugs to the brain thus restricting the effective delivery of therapeutics for neurodegenerative disorders. Recently, greater emphasis has been given for polymeric nanoparticles as a potential delivery system to transport drugs across the blood-brain barrier. This study focuses on the cellular route, localization and enhancement of uptake of drug loaded polymeric nanoparticles for delivery across the blood-brain barrier. We have optimized and synthesized polylactic-co-glycolic acid (PLGA) nanoparticles as a carrier for the delivery of drugs across the barrier. Cell penetrating peptide trans-activating transcriptor (TAT) was conjugated with the polymer through covalent bonding for increasing the efficiency of drug delivery across the BBB. Rhodamine-B was used as a model drug to study the release of drugs from the synthesized nanoparticle and finally the in vivo uptake in a mice model was checked. The size of the synthesized nanoparticles was in the nanometer range and the release profile revealed a rapid release appropriate for brain delivery. The cellular uptake experiments revealed that the peptide conjugated nanoparticle was readily taken up by the cells through macropinocytosis. Finally, to overcome the challenges for drugs to cross the BBB in an in vivo system, we have tracked the bioavailability of the nanoparticles in a mice model. Here we report an enhanced uptake of the peptide functionalized drug delivery carrier to successfully deliver and track therapeutic molecules across the blood-brain barrier in vivo.
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