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Angiotensin I-Converting Enzyme Inhibitor Activity of Nutritive Plants in KwaZulu-Natal
S. Ramesar,H. Baijnath,T. Govender,I. Mackraj 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Traditional herbal remedies still form an integral part of South African culture, hence necessitating reports onthe scientific rationale for their uses. Organic and aqueous extracts from 16 nutritive plants found in KwaZulu-Natal, SouthAfrica were screened for angiotensin I-converting enzyme (ACE) inhibitory activity using a fluorometric enzyme assay. Aplant was considered to have potential antihypertensive properties if it inhibited the ACE enzyme and thus the conversion ofangiotensin I to angiotensin II by greater than 50%. Eight of the 16 plants screened demonstrated ACE inhibitory activity andsatisfied these criteria. These eight plants were then subjected to a gelatin salt block test for tannins to show that the ACE in-hibitory activities were not due to the presence of tannins, as tannins also inhibit ACE activity. The plants that showed ACEinhibitory activity were Amaranthus dubius, Amaranthus hybridus, Asystasia gangetica, Galinsoga parviflora, Justicia flava,Oxygonum sinuatum, Physalis viscosa, and Tulbaghia violacea. T. violaceain particular shows promise with regards to ACEinhibition as in vivo administration of this extract showed only a 2.2% increase in maximum mean arterial pressure whencompared to the 14.5% increase observed in the control group after co-administration with exogenous Ang I.