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이미옥(Mi-Ok Lee),차혁진(Hyuk-Jin Cha) 한국생물공학회 2011 KSBB Journal Vol.26 No.3
Adult stem cells, which have characteristic of self-renewal and multipotency, are specialized cell types, responsible for the tissue regeneration of the damaged tissue. Recent studies suggest that stem cells senescence (or stem cells’ ageing) is closely associated with the variety of ageing-related phenotypes such as tissue atrophy, degenerative diseases and onset of cancers. During ageing, declining of stem cells function and subsequently occurring mal-differentiation of stem cells would be important to understand the biological process of development of ageing-related phenotypes such as tissue degenerations and cancers. This review focuses on the DNA damage stress as a cause of senescence of stem cells and their maldifferentiation, which is closely link to defect of regeneration potentials and neoplastic transformation. Understanding of molecular mechanisms governingsuch events is likely to have important implications for developing novel avenues for balancing tissue homeostasis longer period of time, further leading to ‘Healthy ageing’.
이승종,차혁진 한국화학공학회 1987 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.25 No.3
두 평행원판 사이에 놓여있는 Herschel-Bulkley 모델로 표시되는 점소성 유체가 일정한 하중 하에서 압착될 때 일어나는 압착유동 현상을 이론적으로 해석하여 새로운 근사해를 유도하였다. 이를 이용하여 압착유동곡선으로부터 점소성 유체의 항복응력(τ_0) 및 Herschel-Bulkley 파라미터(n, η_(HB))를 구하는 방법이 제시되었으며, 두가지 시료 물질에 대한 실험 결과는 점소성 유체의 유변물성 측정에 압착유동장치가 충분히 사용될 수 있음을 보여주고 있다. Squeeze film flow of viscoplastic Herschel-Bulkley fluids between two parallel circular plates under a constant load was analyzed theoretically to derive an approximate solution. This solution was used to determine the yield stress (τ_0) and Herschel-Bulkley parameters (n, η_(HB)) of two test materials from their experimental squeezing curves. The results showed that the simple squeeze film apparatus could be used to determine the yield stress and other rheological properties of viscoplastic materials.