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윤현수,노병진,윤성규,강기천,Hyeonsu Yun,Byeongjin Roh,Seong-Kyu Yun,Gichun Kang 한국지반신소재학회 2024 한국지반신소재학회 논문집 Vol.23 No.1
Recently, the frequency and intensity of typhoon-induced wave loading are increasing due to changed marine environments such as climate change. In addition, frequent earthquakes are causing a lot of damage around the world, including in Japan, Chile, Haiti, China, and Indonesia. In Korea, damage from typhoons has also been increasing since the 2000s, and the frequency and intensity of earthquakes are also increasing. Korea is surrounded by sea on three sides, so typhoons can cause a lot of damage to coastal structures, and earthquakes also cause a lot of damage to coastal structures. As such, the frequency and intensity of typhoon-induced wave loading and earthquakes are increasing both domestically and internationally, but there is no research linking typhoons and earthquakes. Therefore, in this study, numerical analysis was performed for a total of four cases by linking typhoon waves and earthquakes to the caisson breakwater. Numerical analysis was performed by applying wave loads in Case 1 and seismic wave in Case 2, seismic wave after wave loads in Case 3, and wave loads after seismic wave in Case 4. As a result of the numerical analysis, it was confirmed that in Case 3 and Case 4, which linked a typhoon and earthquakes, the damage caused by each load increased compared to Case 1 and Case 2 because the load was applied while the existing ground strength was reduced. In addition, it was confirmed that the greatest damage occurred in Case 3, in which seismic wave were applied after the wave loads.
윤현수,윤성규,강기천,Hyeonsu Yun,Seong-Kyu Yun,Gichun Kang 한국지반신소재학회 2024 한국지반신소재학회 논문집 Vol.23 No.2
2017년 포항지진으로 인해 액상화 현상에 의한 안벽구조물에 피해가 발생하였다. 액상화는 지진 시 과잉간극수압 증가로 인해 유효응력이 소실되어 발생하게 된다. 이에 따른 잔교식 안벽의 피해 발생 부분을 규명하며 액상화로 인한 피해를 분석하였다. 또한 개량지반의 경우 연암층과 강성차이로 인해 하부 Sand 층의 액상화 현상으로 인해 피해가 발생하여, 비액상화 지반으로 가정하고 추가적인 수치해석을 수행하였다. 과잉간극수압비의 증가에 영향을 주는 요인으로는 지반의 상대밀도 및 입력 지진가속도의 크기 등 여러 가지 원인이 있다. 따라서 본 연구는 입력가속도의 크기를 증가시켜 Case 1~3에 대해 수치해석을 수행하였고, 개량지반의 경우 하부 Sand층의 액상화 현상으로 인한 피해가 발생하여 비액상화지반으로 가정하여 분석을 수행하였다. 결과적으로, 개량지반은 하부 액상화지반이 있을 경우 추가적인 보강이 필요하며, 잔교식 안벽 말뚝의 수평변위가 약 2배 감소하는 현상이 나타났다. The 2017 Pohang earthquake caused damage to quay structures due to liquefaction. Liquefaction occurs when effective stress is lost due to an increase in excess pore water pressure during an earthquake. As a result, the damage caused to the pier-type quay wall was identified and the damage caused by liquefaction was analyzed. In addition, in the case of improved ground, damage occurred due to liquefaction of the lower sand layer due to the difference in stiffness from the soft rock layer, so additional numerical analysis was performed assuming non-liquefaction ground. There are several factors that affect the increase in excess pore water pressure ratio, such as the relative density of the ground and the magnitude of the input seismic acceleration. Therefore, this study performed numerical analysis for Cases 1 to 3 by increasing the magnitude of the input acceleration, and in the case of improved ground, damage occurred due to liquefaction of the lower sand layer, so the analysis was performed assuming non-liquefaction ground. As a result, the improved ground requires additional reinforcement when there is liquefied ground below, and the horizontal displacement of the pier-type quay piles was reduced by about two times.
( Seung Kak Shin ),( Young Kul Jung ),( Seung Jun Jang ),( Hae Lim Baek ),( Hyun Hwa Yoon ),( Soo Yong Park ),( Min Young Rim ),( Hyeonsu Park ),( In Ku Yo ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Jo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Multi-antiviral drug resistance is a major problem in the treatment of patients with chronic hepatitis B (CHB). Tenofovir disoproxil fumarate (TDF) is recommended for ADV or entecavir (ETV). However, until recently TDF was not available in Korea. ADV and ETV combination therapy may be a viable alternative to TDF in patients with either ADV or ETV resistance. This study investigated the efficacy of ADV and ETV combination therapy in patients with multidrug resistance. Methods: Forty-one patients were enrolled and were administered ADV and ETV combination therapy for at least 12 months. Blood was drawn at baseline and at 12, 24, 36, 48, and 60 months after commencing treatment, and virological response was analyzed. Results: After ADV and ETV combination therapy, ALT normalization was 68%, 73%, 80% 90%, and 93% in 12wks, 24wks, 36wks, 48wks, and 60 wks, respectively. HBV DNA reduction was -1.5, -1.8, -1.9, -1.8, and -1.9 log10IU/mL in 12wks, 24wks, 36wks, 48wks, and 60 wks, respectively. 29 of HBeAg positive patients showed the following low HBeAg seroconversion rate: 3%, 7%, and 10% in 24wks, 48wks, and 60wks, respectively. In addition, virological response group showed lower initial HBV DNA level (P=0.014) and lower HBeAg positive rate (P=0.016) compared with non-virological response group. Conclusions: ADV and ETV combination therapy could be considered in selected chronic hepatitis B patients who have low initial HBV DNA level and HBeAg negative status.
( Hyunhwa Yoon ),( Young Kul Jung ),( Seung Jun Jang ),( Seung Kak Shin ),( Hae Lim Baek ),( Soo Yong Park ),( Min Young Rim ),( Hyeonsu Park ),( In Ku Yo ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Joo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The combination theraphy with peginterferon and ribavirin has been used to treat chronic hepatitis C for several years in Korea, yet there is a few reports regarding the results of the genotype 2, 3. We evaluated factors influencing SVR in Korean patients with genotype 2 and 3 chronic hepatitis C after combination theraphy conducted at a single center. Methods: This study was performed to investigate the factors that affect sustained virologic response (SVR) who underwent combination theraphy consist of peginterferon and ribavirin. Reptrosepctively, a total of 98 patients untreated genotype 2 and 3 chronic hepatitis C were enrolled and completed the treatment (52 males(53.06%), genotype 2: 96 (97.96%)). Duration of the treatment was 16-24 weeks. Response of the treatment was evaluated by rapid virologic response (RVR), end treatment virologic response (ETR) and sustained virologic response (SVR). Results: The RVR, ETR, SVR were 88.78%, 92.86% and 91.84% respectively. The total number of patients who did not have SVR were 8, of which 3 patients were non responsive to antiviral agents, and 5 patients showed evidence of relapse of HCV infection. Among the 5 patients with relapse, dose was not reduced in 2 patients, whereas dose reduction was done to 3 patients who showed adverse effects, such as hematologic disorders (anemia, leukopenia, thrombocytopenia), poor oral intake, and general weakness. Univariate analysis showed that the RVR was the only independent factor that affected the SVR(odds ratio=11.857, 95% confidence interval: 2.427-57.920, P<0.001). Conclusions: Our study showed that combination theraphy with peginterferon and ribavirin as an initial treatment for genotype 2 and 3 chronic hepatitis C is very effective, and that the SVR rate is significantly associated with the RVR and might be a useful response factor that is readily available in clinical practice, and especially for genotype 2 and 3 patients.