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RISS 인기검색어
- 검색키워드
- 저자 : Hwani Ryu (검색결과 4 건)
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성찬용,류능환,윤준노,김영익,임상혁 강원대학교 부설 석재복합신소재 제품연구센터 2003 석재연 논문집 Vol.8 No.-
본 연구는 석분과 황토를 사용한 건자재 제품을 개발하기 위하여 황토의 첨가량를 5종류, 석분의 첨가량을 3종류로 하여 총 16종류의 모르타르에 대하여 단위중량, 흡수율, 압축강도, 휨강도, 동탄성계수, 초음파진동속도, 중성화 깊이에 대하여 구명하였다. 단위중량, 압축강도, 휨강도, 동탄성계수 및 초음파진동속도는 황토와 석분의 사용량이 증가할수록 감소하는 경향을 나타내었고, 흡수율과 중성화 깊이는 증가하는 경향을 나타내었다. 주사전자현미경에 의한 관찰에서는 비활성황토의 사용량이 증가할수록 결정이 증가한 것으로 나타났다. 황토의 사용량은 강도적인 측면에서는 결합재량의 40%까지 사용이 가능하고, 흡수율 측면에서는 10%까지 사용이 가능하며, 건자재의 사용목적에 따라 황토의 사용량을 조절하는 것이 필요할 것으로 생각된다. The purpose of this study is to obtain the basic data for the development of construction materialproducts using stone dust and non-active Hwangto. The results of physical and mechanical properties were as follows. The unit weight, compressive and flexural strengths, dynamic modulus and ultrasonic pulse velocity are decreased with increase of the stone dust and Hwangto. The absorption ratio and neutralization depth are increased with increase of the stone dust and Hwangto. In the results of SEM analysis, the crystals are increased with increase of the non-active Hwangto. Accordingly, the Hwangto may be suitably used as a cement replacement material in the construction material products.
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Lee, Sae-lo-oom,Ryu, Hwani,Son, A-rang,Seo, Bitna,Kim, Jooyoung,Jung, Seung-Youn,Song, Jie-Young,Hwang, Sang-Gu,Ahn, Jiyeon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-
<P>Although many studies have examined the roles of hypoxia and transforming growth factor- (TGF-) <I>β</I> separately in the tumor microenvironment, the effects of simultaneous treatment with hypoxia/reoxygenation and TGF-<I>β</I> on tumor malignancy are unclear. Here, we investigated the effects of redox signaling and oncogenes on cell proliferation and radioresistance in A549 human lung cancer cells in the presence of TGF-<I>β</I> under hypoxia/reoxygenation conditions. Combined treatment with TGF-<I>β</I> and hypoxia activated epidermal growth factor receptor (EGFR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a redox-sensitive transcription factor. Interestingly, Nrf2 knockdown suppressed the effects of combined treatment on EGFR phosphorylation. In addition, blockade of EGFR signaling also suppressed induction of Nrf2 following combined treatment with hypoxia and TGF-<I>β</I>, indicating that the combined treatment induced positive crosstalk between Nrf2 and EGFR. TGF-<I>β</I> and hypoxia/reoxygenation increased the accumulation of reactive oxygen species (ROS), while treatment with N-acetyl-<SMALL>L</SMALL>-cysteine abolished the activation of Nrf2 and EGFR. Treatment with TGF-<I>β</I> under hypoxic conditions increased the proliferation of A549 cells compared with that after vehicle treatment. Moreover, cells treated with the combined treatment exhibited resistance to ionizing radiation (IR), and knockdown of Nrf2 increased IR-induced cell death under these conditions. Thus, taken together, our findings suggested that TGF-<I>β</I> and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through ROS-mediated activation of Nrf2 and EGFR.</P>
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안지연,Ky-Youb Nam,Sae-lo-oom Lee,Hwani Ryu,최현경,송지영 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from 2.90 ± 0.22 to 6.02 ± 0.87, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.
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Ahn, Jiyeon,Nam, Ky-Youb,Lee, Sae-Lo-Oom,Ryu, Hwani,Choi, Hyun Kyung,Song, Jie-Young Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from $2.90{\pm}0.22$ to $6.02{\pm}0.87$, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.
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