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RISS 인기검색어
- 검색키워드
- 저자 : Hunter Don (검색결과 3 건)
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Surface nuclear magnetic resonance signal contribution in conductive terrains
Hunter Don,Kepic Anton Korean Society of Earth and Exploration Geophysici 2005 지구물리와 물리탐사 Vol.8 No.1
To correctly invert and interpret Surface Nuclear Magnetic Resonance (SNMR) data collected in conductive terrains, an accurate estimate of subsurface conductivity structure is required. Given such an estimate, it would be useful to determine, before conducting an SNMR sounding, whether or not the conductivity structure would prevent groundwater being detected. Using SNMR forward modelling, we describe a method of determining the depth range from which most of the SNMR signal originates, given a model of subsurface conductivity structure. We use the method to estimate SNMR depth penetration in a range of halfspace models and show that for conductive halfspaces ($<10{\Omega}.m$) the depth of penetration Is less than 50 m. It is also shown that for these halfspaces, increasing coincident loop size does not significantly improve depth penetration. The results can be used with halfspace approximations of more complicated ID conductivity structures to give a reasonable estimate of the depth range over which signal is obtainable in conductive terrains.
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Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats
Liu, Mei,Choi, Dong-Young,Hunter, Randy L.,Pandya, Jignesh D.,Cass, Wayne A.,Sullivan, Patrick G.,Kim, Hyoung-Chun,Gash, Don M.,Bing, Guoying Blackwell Publishing Ltd 2010 Journal of Neurochemistry Vol.112 No.3
<P><I>J. Neurochem.</I> (2010) <B>112</B>, 773–783.</P><P>Abstract</P><P>Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson’s disease. The purpose of this study was to determine if selective loss of nigrostriatal dopaminergic neurons could be reproduced by systemic exposure of adult Fisher 344 rats to trichloroethylene. In our experiments, oral administration of trichloroethylene induced a significant loss of dopaminergic neurons in the substantia nigra pars compacta in a dose-dependent manner, whereas the number of both cholinergic and GABAergic neurons were not decreased in the striatum. There was a robust decline in striatal levels of 3, 4-dihydroxyphenylacetic acid without a significant depletion of striatal dopamine. Rats treated with trichloroethylene showed defects in rotarod behavior test. We also found a significantly reduced mitochondrial complex I activity with elevated oxidative stress markers and activated microglia in the nigral area. In addition, we observed intracellular &agr;-synuclein accumulation in the dorsal motor nucleus of the vagus nerve, with some in nigral neurons, but little in neurons of cerebral cortex. Overall, our animal model exhibits some important features of Parkinsonism, and further supports that trichloroethylene may be an environmental risk factors for Parkinson’s disease.</P>
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