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Qingxian Jia,Lina Wu,Huayi Li 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.2
This paper addresses the problem of robust actuator fault reconstruction for Takagi-Sugeno (T-S) fuzzy systems subjects to actuator faults, unknown inputs and time-varying delays via a Fuzzy Synthesized Learning and Luenberger Observer (FSL2O). Through a coordinate transformation, the original T-S fuzzy system is decomposed into two subsystems: subsystem-1 effected by actuator faults and subsystem-2 effected by unknown inputs. In the presented FSL2O methodology, a Reduced-Order Fuzzy Learning Observer (ROFLO) is explored for the subsystem1 to reconstruct actuator faults accurately while a Reduced-Order Fuzzy State (Luenberger) Observer (ROFSO) is designed for the subsystem-2 based on the H∞ control technique such that it has strong robustness against the unknown inputs. The synthesized design of the ROFLO and the ROFSO is formulated in a unified manner in terms of Linear Matrix Inequalities (LMIs) that can be conveniently solved using LMI optimization technique. In addition, as a comparison, a full-order FLO is suggested for robust actuator fault reconstruction. Finally, a numerical exampleand simulation are provided to demonstrate the effectiveness of the proposed approaches.
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A New Parameter Estimation Method for a Zipf-like Distribution for Geospatial Data Access
Rui Li,Weifeng WU,Hao Wang,Huayi Wu 한국전자통신연구원 2014 ETRI Journal Vol.36 No.1
Many reports have shown that the access pattern forgeospatial tiles follows Zipf’s law and that its parameter αrepresents the access characteristics. However, visits togeospatial tiles have temporal and spatial popularities, andthe α-value changes as they change. We construct amathematical model to simulate the user’s access behaviorby studying the attributes of frequently visited tile objectsto determine parameter estimation algorithms. Becausethe least squares (LS) method in common use cannotobtain an exact α-value and does not provide a suitable fitto data for frequently visited tiles, we present a newapproach, which uses a moment method of estimation toobtain the value of α when α is close to 1. When α isfurther away from 1, the method uses the associated cachehit ratio for tile access and uses an LS method based on acritical cache size to estimate the value of α. The decreasein the estimation error is presented and discussed in thesection on experiment results. This new method, whichprovides a more accurate estimate of α than earliermethods, promises more effective prediction of requestsfor frequently accessed tiles for better caching and loadbalancing.
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Tian, Shuo,Huang, Yan,Lai, Dong,Wang, Hanfeng,Du, Songliang,Shen, Donglai,Chen, Weihao,Xuan, Yundong,Lu, Yongliang,Feng, Huayi,Zhang, Xiangyi,Zhao, Wenlei,Wang, Chenfeng,Wang, Tao,Wu, Shengpan,Huang, Techno-Press 2022 Advances in nano research Vol.12 No.6
The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.
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