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Yang Chengshun,Hua Tao,Dai Yuchen,Huang Xiaoning,Zhang Dongdong 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3
In this paper, a high-performance nonlinear control technique is presented to address the robust anti-disturbance speed tracking problem for permanent magnet synchronous motors (PMSM) in electric vehicles. In the first step, the dynamic model of PMSM is established, and the controller is designed based on backstepping control. Additionally, consider eliminating the differential noise of the virtual controller and approving the virtual control rate and its derivative through the command filter in order to avoid complicated high-order derivatives. Then, based on the PMSM model, an improved model reference adaptive system (MRAS) is proposed to account for unknown parameter perturbation. Besides, in order to improve the anti-interference capability of the system during operation, a second-order nonlinear disturbance observer model is developed, and the robustness of the system is improved by combining the model with linear sliding mode control. Finally, the stability of the system is established using Lyapunov stability criteria, and the hardware-in-the-loop platform is established to demonstrate that the controller in this paper has excellent anti-interference abilities and robustness.
Expression profiling identified IL-8 as a regulator of homotypic cell-in-cell formation
( Banzhan Ruan ),( Chenxi Wang ),( Ang Chen ),( Jianqing Liang ),( Zubiao Niu ),( You Zheng ),( Jie Fan ),( Lihua Gao ),( Hongyan Huang ),( Xiaoning Wang ),( Qiang Sun ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.8
Homotypic cell-in-cell (CIC) structures forming between cancer cells were proposed to promote tumor evolution via entosis, a nonapoptotic cell death process. However, the mechanisms underlying their formation remained poorly understood. We performed a microarray analysis to identify genes associated with homotypic CIC formation. Cancer cells differing in their ability to form homotypic CIC structures were selected for the study. Association analysis identified 73 probe sets for 62 candidate genes potentially involved in CIC formation. Among them, twenty-one genes were downregulated while 41 genes were upregulated. Pathway analysis identified a gene interaction network centered on IL-8, which was upregulated in high CIC cells. Remarkably, CIC formation was significantly inhibited by IL-8 knockdown and enhanced upon recombinant IL-8 treatment, which correlated with altered cell-cell adhesion and expression of adhesive molecules such as P-cadherin and γ-catenin. Together, our work identified IL-8 as a positive regulator of homotypic CIC formation via enhancing intercellular adhesion. [BMB Reports 2018; 51(8): 412-417]