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RISS 인기검색어
- 검색키워드
- 저자 : Hossein Mirkhani (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Fahimeh Kamali,Hossein Mirkhani,Ahmadreza Nematollahi,Saeed Heidari,Elahesadat Moosavi,Marzieh Mohamadi 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.2
Transcutaneous electrical nerve stimulation (TENS) is awidely-practiced method to increase blood flow in clinical practice. The best location for stimulation to achieve optimal blood flow has not yet been determined. We compared the effect of TENS application at sympathetic ganglions and acupuncture points on blood flow in the foot of healthy individuals. Seventy-five healthy individuals were randomly assigned to three groups. The first group received cutaneous electrical stimulation at the thoracolumbar sympathetic ganglions. Thesecond group received stimulation at acupuncture points. Thethird group received stimulation in the mid-calf area as a control group. Blood flowwas recorded at time zero as baseline and every 3 minutes after baseline during stimulation, with a laser Doppler flow-meter. Individuals who received sympathetic ganglion stimulation showed significantly greater blood flow than those receiving acupuncture point stimulation or those in the control group (p < 0.001). Data analysis revealed that blood flow at different times during stimulation increased significantly from time zero in each group. Therefore, the application of lowfrequency TENS at the thoracolumbar sympathetic ganglions was more effective in increasing peripheral blood circulation than stimulation at acupuncture points.
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Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model
Aida Doostkam,Hossein Mirkhani,Kamyar Iravani,Saied Karbalay-Doust,Kazem Zarei 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.3
Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model. Methods. Forty Sprague-Dawley rats were randomly assigned to the following groups: group 1, control; group 2, diabetic rats; and groups 3–5, rats treated with rutin (at doses of 50, 100, and 150 mg/kg, respectively). We used auditory brain stem response, stereology of the spiral ganglion, and measurements of superoxide dismutase (SOD) and malondialdehyde (MDA) to evaluate the effects of treatment. Results. Significant improvements in auditory neuropathy were observed in the rutin-treated groups in comparison with the diabetic group (P<0.05). Auditory threshold, wave latency, wave morphology, the volume and number of neurons in the spiral ganglion, and SOD and MDA activity showed improvements following treatment. Conclusion. Rutin shows promise as a treatment modality for diabetic auditory neuropathy, but more trials are warranted for its clinical application.
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Stereological study of the diabetic heart of male rats
Ali Noorafshan,Hajar Khazraei,Hossein Mirkhani,Saied Karbalay-Doust 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.1
The present study aimed to quantitatively compare the normal and diabetic hearts of rats using stereological methods. Diabetic and control rats received streptozotocin (60 mg/kg) and no treatments, respectively. On the 56<sup>th</sup> day, the hearts were removed and their total volume was estimated using isotropic Cavalieri method. The total volume of the connective tissues and vessels, total length and diameter of the vessels, total number of cardiomyocytes nuclei, and the mean volume of the cardiomyocytes were estimated, as well. In comparison to the control animals, 60 and 43% increase was observed in the total volume of the connective tissue and microvessels of the diabetic rats, respectively (P<0.05). The percent of the vessel profiles with the diameter of 2-4 μm was decreased, while the percent of the vessel profiles with the diameter of 4.1-8 μm was increased in the diabetic hearts (P<0.05). No significant difference was found in the vessels with more than 8 μm diameters. The total number of the cardiomyocytes" nuclei and the number-weighted mean volume were respectively decreased by 37 and 64% in the diabetic group (P<0.01). A significant difference was observed between the two groups concerning the left ventricle volume to body weight ratio as an index for ventricular hypertrophy (P<0.05), while no difference was found regarding the right ventricle to body weight ratio. It can be concluded that diabetes can induce structural changes, including loss and/or atrophy of the cardiomyocytes, accompanied with increase in the connective tissue in the rats" hearts.
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