Bag Carrying Method during Level Walking Affects Perceived Exertion Ratings without Altering Energy Cost, Oxygen Consumption, and Heart Rate in Healthy Adults: A Randomized Crossover Trial

Hiroto Honda(Hiroto Honda ),Reina Maeda(Reina Maeda ),Suguru Ando(Suguru Ando ),Kenji Shinbo(Kenji Shinbo ),Wataru Nanikawa(Wataru Nanikawa ),Masaki Iwamura(Masaki Iwamura ),Yoshihiro Yamashina(Yoshih 사피엔시아 2020 Exercise Medicine Vol.4 No.-

Objectives: Little is known regarding the associations between Borg’s rating of perceived exertion (RPE), cardiopulmonary responses, and carrying bags while level walking. We investigated the changes in RPE and cardiopulmonary responses, including energy cost (EC), oxygen consumption (VdotO₂), and heart rate (HR), when walking with a bag. Methods: This randomized crossover study included 10 healthy adults (aged 21–22 years). Four days of experiments were performed at intervals of 1–2 weeks. The participants walked on a level treadmill while carrying a bag with a strap weighting 5 kg, placed diagonally on their shoulders (DS), vertically on their shoulders (VS), vertically in one hand (VH), and on their backs using both shoulders (BS) for 20 min. Walking speed was stable among all experiments, and was set to the participants’ preferred speed. Results: No significant differences between bag carrying methods regarding EC, VdotO₂, and %HRreserve (based on HR) were observed, whereas RPE respiratory (RPE-resp) and RPE leg muscle (RPE-leg) scores varied based on bag carrying method used. RPE-resp score was significantly lower for DS and BS than VH (both p < 0.0083); however, no significant difference was observed when each RPE-leg score was compared. Conclusions: We found that RPE-resp score varied, whereas no changes in EC, VdotO₂, and HR were observed in healthy adults while walking with different bag carrying methods. Additionally, of all bag carrying methods assessed, the highest RPE-resp score was observed when individuals carried a bag with one-hand at their side.

The Impact of Multiple Roles on Psychological Distress among Japanese Workers

Honda, Ayumi,Abe, Yasuyo,Date, Yutaka,Honda, Sumihisa Occupational Safety and Health Research Institute 2015 Safety and health at work Vol.6 No.2

Background: There has been considerable interest in Japanese society in the problem of work-related stress leading to depressive symptoms, and an increasing number of primary houseworkers maintain paid employment. The purpose of this study was to examine the differential impact of multiple roles associated with psychological distress among Japanese workers. Methods: We studied 722 men and women aged 18-83 years in a cross-sectional study. The K10 questionnaire was used to examine psychological distress. Results: The proportion of participants with psychological distress was higher in women (17.8%) compared with men (11.5%). Having three roles significantly decreased the risk of psychological distress [women: odds ratio (OR), 0.37-fold; men: OR, 0.41] compared with only one role. In working married women, there was significantly less psychological distress (OR, 0.27), and those with childrearing or caregiving responsibilities for elderly parents had significantly less psychological distress (OR, 0.38) than those with only an employment role. Similarly, working married men who had childrearing or caregiving responsibilities for elderly parents had significantly less psychological distress (OR, 0.41) than those who had only an employment role. Conclusion: The present study demonstrated that participants who had only an employment role had an increased risk of psychological distress. The degree of psychological distress was not determined solely by the number of roles. It is important to have balance between work and family life to reduce role conflict and/or role submersion, which in turn may reduce the risk of psychological distress.

Work-related Stress, Caregiver Role, and Depressive Symptoms among Japanese Workers

Honda, Ayumi,Date, Yutaka,Abe, Yasuyo,Aoyagi, Kiyoshi,Honda, Sumihisa Occupational Safety and Health Research Institute 2014 Safety and health at work Vol.5 No.1

Background: In Japan, more than 60% of employees are reported to suffer from anxiety and stress. Consequently, Japanese society has begun to address such important issues as psychogenic disability and job-related suicide. Furthermore, given the aging of society and the surge in the number of elderly people requiring care, it is necessary to adequately and proactively support employees who care for their elderly relatives. The purpose of the present study was to investigate caregiver burden in caring for elderly relatives and work-related stress factors associated with mental health among employees. Methods: We studied 722 men and women aged 18-83 years in a cross-sectional study. The K10 questionnaire was used to examine mental health status. Results: The proportion of participants with a high K10 score was 15% (n = 106). Having little conversation with their supervisor and/or coworkers significantly increased the risk of depression [odds ratio (OR) 1.8], as did high job overload (OR 2.7) and job dissatisfaction (OR 3.8), compared with employees who frequently conversed with their supervisor and/or coworkers. Caring for elderly relatives as a prominent characteristic of an employee was a significant risk factor for depression (OR 2.1). Conclusion: The present study demonstrated that employees who were caring for elderly relatives were significantly associated with an increased risk of depression. To prevent depressive disorders, it may be important to focus on reducing the work-caregiving role conflict, as well as enhancing employees' job control and better rewarding their efforts in the workplace.

The Impact of Multiple Roles on Psychological Distress among Japanese Workers

Ayumi Honda,Yasuyo Abe,Yutaka Date,Sumihisa Honda 한국산업안전보건공단 산업안전보건연구원 2015 Safety and health at work Vol.6 No.2

Background: There has been considerable interest in Japanese society in the problem of work-related stress leading to depressive symptoms, and an increasing number of primary houseworkers maintain paid employment. The purpose of this study was to examine the differential impact of multiple roles associated with psychological distress among Japanese workers. Methods: We studied 722 men and women aged 18e83 years in a cross-sectional study. The K10 questionnaire was used to examine psychological distress. Results: The proportion of participants with psychological distress was higher in women (17.8%) compared with men (11.5%). Having three roles significantly decreased the risk of psychological distress [women: odds ratio (OR), 0.37-fold; men: OR, 0.41] compared with only one role. In working married women, there was significantly less psychological distress (OR, 0.27), and those with childrearing or caregiving responsibilities for elderly parents had significantly less psychological distress (OR, 0.38) than those with only an employment role. Similarly, working married men who had childrearing or caregiving responsibilities for elderly parents had significantly less psychological distress (OR, 0.41) than those who had only an employment role. Conclusion: The present study demonstrated that participants who had only an employment role had an increased risk of psychological distress. The degree of psychological distress was not determined solely by the number of roles. It is important to have balance between work and family life to reduce role conflict and/or role submersion, which in turn may reduce the risk of psychological distress.

Hybrid Steering Model depending on Driver’s Gazing Point to detect inattentive driving using Machine Learning

Takuya Honda,Nobutomo Matsunaga,Hiroshi Okajima 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10

The modeling of driving behaviors is important to analyze and design comfortable functions for the driving systems. The estimation method of the non-linear steering model using the eye tracking information was studied using the heuristic search algorithm. However, the model was limited to gaze and the inattentive driving was not modeled. It is considered that the steering model is consists of a hybrid steering model that switches the controllers according to the eye tracking information is classified in the effective/peripheral viewing field. In this paper, an estimation method of the hybrid system focusing on the effective visual field during driving is proposed. The hybrid model is constructed by steering model depending on the gazing distance and simple on-off controller. This estimation algorithm consists of 2-steps; clustering which classifies data by k-means method and the estimation of the parameters by Particle Swarm Optimization. The experiment with the long driving course consisting of five-curves and straight lines is demonstrated by HONDA driving simulator.

Work-related Stress, Caregiver Role, and Depressive Symptoms among Japanese Workers

Ayumi Honda,Yutaka Date,Yasuyo Abe,Kiyoshi Aoyagi,Sumihisa Honda 한국산업안전보건공단 산업안전보건연구원 2014 Safety and health at work Vol.5 No.1

BackgroundIn Japan, more than 60% of employees are reported to suffer from anxiety and stress. Consequently, Japanese society has begun to address such important issues as psychogenic disability and job-related suicide. Furthermore, given the aging of society and the surge in the number of elderly people requiring care, it is necessary to adequately and proactively support employees who care for their elderly relatives. The purpose of the present study was to investigate caregiver burden in caring for elderly relatives and work-related stress factors associated with mental health among employees. MethodsWe studied 722 men and women aged 18–83 years in a cross-sectional study. The K10 questionnaire was used to examine mental health status. ResultsThe proportion of participants with a high K10 score was 15% (n = 106). Having little conversation with their supervisor and/or coworkers significantly increased the risk of depression [odds ratio (OR) 1.8], as did high job overload (OR 2.7) and job dissatisfaction (OR 3.8), compared with employees who frequently conversed with their supervisor and/or coworkers. Caring for elderly relatives as a prominent characteristic of an employee was a significant risk factor for depression (OR 2.1). ConclusionThe present study demonstrated that employees who were caring for elderly relatives were significantly associated with an increased risk of depression. To prevent depressive disorders, it may be important to focus on reducing the work-caregiving role conflict, as well as enhancing employees' job control and better rewarding their efforts in the workplace.

Control of electron-transfer reduction by protonation of zinc octabutoxyphthalocyanine assisted by intramolecular hydrogen bonding

Honda, Tatsuhiko,Kojima, Takahiko,Fukuzumi, Shunichi Royal Society of Chemistry 2011 Chemical communications Vol.47 No.28

<P>Facile protonation of α-octabutoxyphthalocyaninato zinc(<SMALL>II</SMALL>) (Zn(OBu)<SUB>8</SUB>Pc) occurs to afford up to tetra-protonated species stabilized by intramolecular hydrogen bonding, resulting in positive shifts of the reduction potentials of Zn(OBu)<SUB>8</SUB>PcH<SUB><I>n</I></SUB><SUP><I>n</I>+</SUP> (<I>n</I> = 1–4) with increasing the number of protons attached to facilitate electron-transfer reduction.</P> <P>Graphic Abstract</P><P>We demonstrate that the facile protonation of α-octabutoxyphthalocyaninato zinc<SMALL>II</SMALL> stabilized by intramolecular hydrogen bonding results in positive shifts of the reduction potentials to facilitate the electron-transfer reduction. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc12710a'> </P>

Direct test of the AdS/CFT correspondence by Monte Carlo studies of $ \mathcal{N}=4 $ super Yang-Mills theory

Honda, Masazumi,Ishiki, Goro,Kim, Sang-Woo,Nishimura, Jun,Tsuchiya, Asato Springer-Verlag 2013 Journal of high energy physics Vol.2013 No.11

Proton-Coupled Electron-TransferReduction of DioxygenCatalyzed by a Saddle-Distorted Cobalt Phthalocyanine

Honda, Tatsuhiko,Kojima, Takahiko,Fukuzumi, Shunichi American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.9

<P>Proton-coupled electron-transfer reduction of dioxygen(O<SUB>2</SUB>) to afford hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) was investigatedby using ferrocene derivatives as reductants and saddle-distorted(α-octaphenylphthalocyaninato)cobalt(II) (Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc)) as a catalyst under acidic conditions.The selective two-electron reduction of O<SUB>2</SUB> by dimethylferrocene(Me<SUB>2</SUB>Fc) and decamethylferrocene (Me<SUB>10</SUB>Fc) occursto yield H<SUB>2</SUB>O<SUB>2</SUB> and the corresponding ferroceniumions (Me<SUB>2</SUB>Fc<SUP>+</SUP> and Me<SUB>10</SUB>Fc<SUP>+</SUP>, respectively). Mechanisms of the catalytic reduction of O<SUB>2</SUB> are discussed on the basis of detailed kinetics studies on the overallcatalytic reactions as well as on each redox reaction in the catalyticcycle. The active species to react with O<SUB>2</SUB> in the catalyticreaction is switched from Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc) to protonated Co<SUP>I</SUP>(Ph<SUB>8</SUB>PcH), depending on thereducing ability of ferrocene derivatives employed. The protonationof Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc) inhibits thedirect reduction of O<SUB>2</SUB>; however, the proton-coupled electrontransfer from Me<SUB>10</SUB>Fc to Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc) and the protonated [Co<SUP>II</SUP>(Ph<SUB>8</SUB>PcH)]<SUP>+</SUP> occurs to produce Co<SUP>I</SUP>(Ph<SUB>8</SUB>PcH) and [Co<SUP>I</SUP>(Ph<SUB>8</SUB>PcH<SUB>2</SUB>)]<SUP>+</SUP>, respectively,which react immediately with O<SUB>2</SUB>. The rate-determining stepis a proton-coupled electron-transfer reduction of O<SUB>2</SUB> byCo<SUP>II</SUP>(Ph<SUB>8</SUB>Pc) in the Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc)-catalyzed cycle with Me<SUB>2</SUB>Fc, whereas it is changed to the electron-transfer reduction of [Co<SUP>II</SUP>(Ph<SUB>8</SUB>PcH)]<SUP>+</SUP> by Me<SUB>10</SUB>Fc inthe Co<SUP>I</SUP>(Ph<SUB>8</SUB>PcH)-catalyzed cycle with Me<SUB>10</SUB>Fc. A single crystal of monoprotonated [Co<SUP>III</SUP>(Ph<SUB>8</SUB>Pc)]<SUP>+</SUP>, [Co<SUP>III</SUP>Cl<SUB>2</SUB>(Ph<SUB>8</SUB>PcH)], produced by the proton-coupled electron-transferreduction of O<SUB>2</SUB> by Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc) with HCl, was obtained, and the crystal structure wasdetermined in comparison with that of Co<SUP>II</SUP>(Ph<SUB>8</SUB>Pc).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-9/ja209978q/production/images/medium/ja-2011-09978q_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja209978q'>ACS Electronic Supporting Info</A></P>

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

Honda, Fumiko,Kano, Hirotsugu,Kanegane, Hirokazu,Nonoyama, Shigeaki,Kim, Eun-Sung,Lee, Sang-Kyou,Takagi, Masatoshi,Mizutani, Shuki,Morio, Tomohiro Nature Publishing Group, a division of Macmillan P 2012 NATURE IMMUNOLOGY Vol.13 No.4

The function of the kinase Btk in neutrophil activation is largely unexplored. Here we found that Btk-deficient neutrophils had more production of reactive oxygen species (ROS) after engagement of Toll-like receptors (TLRs) or receptors for tumor-necrosis factor (TNF), which was associated with more apoptosis and was reversed by transduction of recombinant Btk. Btk-deficient neutrophils in the resting state showed hyperphosphorylation and activation of phosphatidylinositol-3-OH kinase (PI(3)K) and protein tyrosine kinases (PTKs) and were in a 'primed' state with plasma membrane??associated GTPase Rac2. In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm. Our data identify Btk as a critical gatekeeper of neutrophil responses.