http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hiroshi Aonuma (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Toyohito Segawa,Naohisa Miyakoshi,Yuji Kasukawa,Hiroshi Aonuma,Hiroyuki Tsuchie,Yoichi Shimada 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.1
Objectives: Reduced bone quality caused by vitamin C deficiency in older persons may lead to incidental fragility fractures during bisphosphonate treatment, although bisphosphonate increases bone mineral density (BMD). This study aimed to evaluate the effects of minodronate and ascorbic acid (Aa) on BMD, bone quality, and bone strength in Aa-deficient osteogenic disorder Shionogi (ODS) rats. Methods: Six-month-old ODS rats were divided into four groups (n ¼ 20 per group): (1) Aa supplementation (Aa þ ); (2) Aa-deficient (Aa ? ); (3) Aa supplementation and minodronate administration (Aaþ þ Mino); and (4) Aa-deficient and minodronate administration (Aa? þ Mino). BMD, bone strength, bone histomorphometry, and bone quality determined using Fourier transform infrared spectroscopy imaging (FTIRI) were evaluated after 4 and 8 weeks. Results: BMD was significantly higher in the Aaþ þ Mino group than in the Aa? group ( p < 0.05). Bone strength was significantly higher in the Aaþ and Aaþ þ Mino groups than in the Aa? group ( p < 0.05). Furthermore, bone strength was significantly higher in the Aaþ þ Mino group than in the Aa? þ Mino group ( p < 0.05). Minodronate treatment irrespective of Aa supplementation significantly decreased bone resorption compared with the Aaþ and Aa? groups ( p < 0.05). No significant differences in the parameters evaluated by FTIRI were observed between the groups. Conclusions: Aa supplementation improved bone strength in ODS rats. Combined treatment with minodronate and Aa, but not minodronate alone, improved bone strength and increased BMD. Aa is required for bone health because it is essential for osteoblast differentiation. © 2016 The Korean Society of Osteoporosis. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
