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RISS 인기검색어
- 검색키워드
- 저자 : Hiroaki Nanba (검색결과 3 건)
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Effect of Maitake (Grifola frondosa) D-Fraction on the Activation of NK Cells in Cancer Patients
Noriko Kodama,Kiyoshi Komuta,Hiroaki Nanba 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4
Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tu-mor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells.In a previous study, the combination of immunotherapy with the maitake D-Fraction and chemotherapy suggested that the D-Fraction may have the potential to decrease the size of lung, liver, and breast tumors in cancer patients. In the present study,we administered maitake D-Fraction to cancer patients without anticancer drugs, and at the same time NK cell activity wasmonitored to investigate whether the activity is closely related with disease progression. The numbers of CD4 1 and CD81cells in the peripheral blood were measured in 10 patients, and NK cell activity was assessed using K-562 cells as target cells.Serum soluble interleukin-2 receptor (sIL-2R) levels in three patients and the expression of tumor markers in four patientswere determined by enzyme-linked immunosorbent assay. The slight changes observed in the CD4 1 and CD81 cell numberswere independent of disease severity or stage as well as serum sIL-2R levels. In contrast, maitake D-Fraction hindered metasta-tic progress, lessened the expression of tumor markers, and increased NK cell activity in all patients examined. Thus maitakeD-Fraction appears to repress cancer progression and primarily exerts its effect through stimulation of NK activity. In addi-tion, we conclude that measurement of NK cell activity may be a useful clinical parameter in monitoring disease progressionduring and following immunotherapy with maitake D-Fraction.
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Noriko Kodama,Shigeto Mizuno,Hiroaki Nanba,Naoaki Saito 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Edible mushrooms contain an abundance of immune-enhancing nutrients. Some of these compounds, referred to as biological response modifiers (BRMs), have been used in biological therapies for cancer treatment. We obtained a low-molecular-weight protein fraction (MLP-Fraction) from the fruiting body of the maitake mushroom Grifola frondosa by multiple sequential steps, including ethanol precipitation, DEAE-exchange chromatography, and gel filtration. The effect of the MLP-Fraction on the immune system was determined using normal mice. This resulted in a simultaneous increase in splenocyte proliferation and production of cytokines such as interleukin (IL)-1α, tumor necrosis factor-α, IL-10, IL-12, and interferon (IFN)-γ. The expression levels of IFN-γ and IL-12 in antigen-presenting cells (APCs) and the activation of natural killer (NK) cells, macrophages, and dendritic cells were observed. These results suggest a mechanism in which NK cells are activated through cytokines produced by APCs. We also confirmed the possibility that the MLP-Fraction acts as a BRM using colon-26 carcinoma-bearing mice. This fraction enhanced the production of IL-12 and IFN-γ by splenocytes in tumor-bearing mice and clearly showed an inhibitory effect on tumor cell growth.
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