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Lee, Sang Jin,Heo, Dong Nyoung,Lee, Hak Rae,Lee, Donghyun,Yu, Seung Jung,Park, Su A,Ko, Wan-Kyu,Park, Se Woong,Im, Sung Gap,Moon, Ji-Hoi,Kwon, Il Keun The Royal Society of Chemistry 2015 Journal of materials chemistry. B, Materials for b Vol.3 No.26
<P>In the last decade, titanium has been effectively used in the dental field for oral surgery as an implant material. However, disinfected Ti can be easily re-infected by the surrounding environment. Thus, a novel anti-fouling treatment for Ti implants is currently necessary. In this study, we designed an anti-fouling surface comprised of poly<I>N</I>-isopropylacylamide (PIPAAM) grafted Ti by introducing poly glycidyl methacrylate (pGMA) coating<I>via</I>an initiated chemical vapor deposition (iCVD) system to prevent bacterial infection. The results indicate that pristine Ti was well coated with pGMA with a film thickness of approximately 60 nm and uniformly grafted with PIPAAM. The bacteria were effectively detached after rinsing with a buffer solution at room temperature, while hADSCs were well attached on the surface treated Ti surface at oral temperature. All tests clearly confirm that our strategy may be a useful means of imparting anti-fouling characteristics to Ti in order to prevent bacterial adhesion and resultant peri-implantitis.</P>