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COLLABORATION BETWEEN PROFESSIONAL INSTITUTIONS IN RAISING THE PROFILE OF ASTRONOMY RESEARCH

HENGST, SHANE,AKHTER, SHAILA The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
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  ScienceON
  
  코리아스칼라
The Physics Outreach Unit at UNSW Australia contributes to the goals of the IAU's Commission 55 by collaborating with established institutions to improve public engagement with science. We aim to not only increase public awareness of astronomy but also ensure the benefits to society of our scientific endeavours are understood. We have found collaborating with like-minded institutions who are working in similar spaces allows both parties to make a larger impact than working alone. For example, our long-term collaboration with the Australian Museum provides the opportunity to engage urban and rural communities with science, audiences to which we do not normally have easy access. To increase our national presence we are exploring new relationships with other institutions, in particular the Astronomical Society of Australia (ASA), in hosting events such as public talks with eminent astronomers, star parties and astronomical workshops. These partnerships help build firm foundations for planning future events, in particular during the International Year of Light 2015.
2
Reprogramming axonal behavior by axon-specific viral transduction

Walker, B A,Hengst, U,Kim, H J,Jeon, N L,Schmidt, E F,Heintz, N,Milner, T A,Jaffrey, S R Nature Publishing Group 2012 Gene Therapy Vol.19 No.9
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The treatment of axonal disorders, such as diseases associated with axonal injury and degeneration, is limited by the inability to directly target therapeutic protein expression to injured axons. Current gene therapy approaches rely on infection and transcription of viral genes in the cell body. Here, we describe an approach to target gene expression selectively to axons. Using a genetically engineered mouse containing epitope-labeled ribosomes, we find that neurons in adult animals contain ribosomes in distal axons. To use axonal ribosomes to alter local protein expression, we utilized a Sindbis virus containing an RNA genome that has been modified so that it can be directly used as a template for translation. Selective application of this virus to axons leads to local translation of heterologous proteins. Furthermore, we demonstrate that selective axonal protein expression can be used to modify axonal signaling in cultured neurons, enabling axons to grow over inhibitory substrates typically encountered following axonal injury. We also show that this viral approach also can be used to achieve heterologous expression in axons of living animals, indicating that this approach can be used to alter the axonal proteome in vivo. Together, these data identify a novel strategy to manipulate protein expression in axons, and provides a novel approach for using gene therapies for disorders of axonal function.