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RISS 인기검색어
- 검색키워드
- 저자 : Heidrun B. Gross (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Effects of a Flavonol-Rich Diet on Select Cardiovascular Parameters in a Golden Syrian Hamster Model
Swati Kalgaonkar,Heidrun B. Gross,Wallace Yokoyama,Carl L. Keen 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
The concept that the consumption of a diet rich in flavonoids can be associated with a reduced risk for cardiovascular disease is becoming increasingly accepted. In the present study we investigated the effects of the following four diets on blood pressure and cholesterol ester levels in hypercholesterolemic Golden Syrian hamsters: a high-fat, high-cholesterol diet (HFHC); a HFHC with 2% cranberry concentrate powder (HFHC+CE); a HFHC with 0.1% rutin (HFHC+Rutin); and a HFHC with 30mg/kg vitamin E (HFHC+Vit.E). Diets were fed for either 12 or 20 weeks. Over the experimental period, heart rate and blood pressure measurements increased in the animals fed HFHC and HFHC+Vit.E; in contrast, these measurements were not increased in the animals fed HFHC+CE and HFHC+Rutin. Mesenteric and total abdominal fat were significantly lower in the animals fed HFHC+Rutin than in animals fed the other three diets. Ratios of plasma high-density lipoprotein cholesterol (HDL-C) to very-low-density lipoprotein cholesterol and of plasma HDL-C to low-density lipoprotein cholesterol were significantly higher in animals consuming HFHC+Vit.E than in animals fed the other three diets. Aortic cholesteryl ester levels were significantly lower in animals fed HFHC+CE, HFHC+Rutin, and HFHC+Vit.E at 20 weeks than in the animals fed HFHC. Fasting blood glucose concentrations were significantly lower in animals fed HFHC+Rutin and HFHC+Vit.E, and glucose clearance rates improved in animals fed HFHC+Rutin compared to animals fed the other three diets. Results obtained from this study support the concept that the chronic consumption of a flavonoid-rich diet can be beneficial with respect to cardiovascular health.
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Robert M. Hackman,John A. Polagruto,Heidrun B. Gross,Faranak Kamangar,Ken-Ichi Kosuna,Buxiang Sun,Hajime Fujii,Carl L. Keen 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4
Epidemiological studies suggest that a high dietary intake of flavanols, a subclass of flavonoids, is associatedwith reduced risk of vascular disease. Clinical studies have also shown that the consumption of certain flavanol-rich foods(e.g., cocoa, tea, red wine), as well as intake of the individual flavanol (-)-epicatechin, can result in improvement in a num-ber of parameters associated with vascular disease, including improved endothelial function, reduced platelet reactivity, andreduced oxidative stress. The present study assessed the effects of a flavanol-rich supplement on platelet reactivity and plasmaoxidant defense in a group of smokers, a population at an elevated risk for vascular disease. Male smokers were randomlyassigned to a placebo (n . 10) or a flavanol-rich grapeseed extract (FRGSE; n . 13) group, and after an overnight fast, bloodsamples were collected before and at 1, 2, and 6 hours following consumption of the placebo or supplement. The FRGSE sup-plement, but not the placebo, significantly decreased ADP-stimulated platelet reactivity at 1, 2, and 6 hours following intake(P. .05) compared to baseline levels. Similarly, the supplement, but not the placebo, decreased epinephrine-stimulated plateletreactivity 2 hours following consumption. Plasma antioxidant capacity (total radical trapping antioxidant potential), lipid ox-idation (plasma thiobarbituric acid-reactive substances), and serum uric acid concentrations were not affected in either group.Thus smokers may obtain some health benefits from the consumption of certain flavanol-rich foods, beverages, and supple-ments.
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