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        INVESTIGATION OF REGENERATIVE AND ANTI-LOCK BRAKING INTERACTION

        S. A. OLEKSOWICZ,K. J. BURNHAM,P. BARBER,B. TOTH-ANTAL,G. WAITE,G. HARDWICK,C. HARRINGTON,J. CHAPMAN 한국자동차공학회 2013 International journal of automotive technology Vol.14 No.4

        The use of a regenerative braking mode can reduce overall vehicle energy usage for most of the most common drive cycles. However, a number of technical issues restrict the use of regenerative braking for all possible braking situations. These issues are concerned with two key limitations. The first is related to physical limitations of the applied regenerative braking system, e.g. Electric Motor (E-Motor) power limits; energy storage device capacity and vehicle load transfer etc. The second limitation results from the potentially detrimental interaction between regenerative braking and the Anti-locking Braking System (ABS). The first type of limitation can, to some extent, be alleviated by suitable choice of hardware and, as a consequence, will not be discussed further in this paper. The second type of limitation concerns the regenerative braking strategies during an ABS event. Some of the regenerative braking strategies designed and investigated within the Low Carbon Vehicle Technology Project (LCVTP) will be described and analyzed in this paper. A comparison of competing strategies is made and conclusions are drawn together with suggestions for further research. The work has been progressed as a part of a major research programme; namely the LCVTP, which has been conducted within an extensive industrial and academic partnership, mutually funded by the European Regional Development Found and Advantage West Midlands.

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        Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B

        Buttrick, Graham J.,Meadows, John C.,Lancaster, Theresa C.,Vanoosthuyse, Vincent,Shepperd, Lindsey A.,Hoe, Kwang-Lae,Kim, Dong-Uk,Park, Han-Oh,Hardwick, Kevin G.,Millar, Jonathan B. A. The American Society for Cell Biology 2011 Molecular biology of the cell Vol.22 No.23

        <P>Type 1 phosphatase (PP1) antagonizes Aurora B kinase to stabilize kinetochore–microtubule attachments and to silence the spindle checkpoint. We screened for factors that exacerbate the growth defect of <I>Δdis2</I> cells, which lack one of two catalytic subunits of PP1 in fission yeast, and identified Nsk1, a novel protein required for accurate chromosome segregation. During interphase, Nsk1 resides in the nucleolus but spreads throughout the nucleoplasm as cells enter mitosis. Following dephosphorylation by Clp1 (Cdc14-like) phosphatase and at least one other phosphatase, Nsk1 localizes to the interface between kinetochores and the inner face of the spindle pole body during anaphase. In the absence of Nsk1, some kinetochores become detached from spindle poles during anaphase B. If this occurs late in anaphase B, then the sister chromatids of unclustered kinetochores segregate to the correct daughter cell. These unclustered kinetochores are efficiently captured, retrieved, bioriented, and segregated during the following mitosis, as long as Dis2 is present. However, if kinetochores are detached from a spindle pole early in anaphase B, then these sister chromatids become missegregated. These data suggest Nsk1 ensures accurate chromosome segregation by promoting the tethering of kinetochores to spindle poles during anaphase B.</P>

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