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        Evaluation of efforts in untrained Wistar rats following exercise on forced running wheel at maximal lactate steady state

        ( Sajjad Rezaei ),( Hamid Agha-alinejad ),( Mahdieh Molanouri Shamsi ),( Mahvash Jafari ),( Fabricio Azevedo Voltarelli ),( Alireza Naderi ),( Conrad Earnest ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.1

        [Purpose] We aimed to examine the effect of running speed on metabolic responses associated with maximal lactate steady state (MLSS) in rats during forced running wheel (FRW) exercise. [Methods] Forty male adult Wistar rats were divided into seven groups. The blood lactate threshold and peak running speed were determined for an incremental power test group. Five groups participated in constant power tests at intensities 10, 13, 14.5, 16, and 17.5 m/min to determine MLSS and a non-exercise group was chosen as the control. Animals were euthanized immediately after constant power tests and their corticosterone, non-esterified fatty acid (NEFA), blood glucose, and creatine kinase (CK) levels analyzed. The differences among groups were identified by one-way analysis of variance (p < 0.05). [Results] Blood lactate threshold corresponded a running intensity of 15 m/min, while MLSS was determined to be 16 m/min. Serum corticosterone concentrations were significantly higher in 14.5, 16, and 17.5 m/ min groups (298.8±62, 338.3±65, and 354±26 nM, respectively) as compared to that in the control group (210.6±16 nM). Concentrations of NEFA observed in groups 13, 14.5, 16, and 17.5 m/min (662.8±24, 702.35±69, 718.4±34, and 752.8±77 μM, respectively) were significantly higher than those in 10 m/min and control groups (511.1±53 and 412.1±56 μM, respectively). The serum CK concentration recorded for group 17.5 m/min (372.4±56 U/ L) was higher than those recorded for other groups. [Conclusion] The speed above 16 m/min on FRW resulted in increased physiological demands and muscle damage in untrained healthy Wistar rats.

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        Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males

        Majid S. Koozehchian,Amin Daneshfar,Ebrahim Fallah,Hamid Agha-alinejad,Mohammad Samadi,Mojtaba Kaviani,Maryam Kaveh B,Y. Peter Jung,Mozhgan Hassanzadeh Sablouei,Najmeh Moradi,Conrad P. Earnest,T. Jeff 한국운동영양학회 2018 Physical Activity and Nutrition (Phys Act Nutr) Vol.22 No.4

        [Purpose] Studies of L-carnitine in healthy athletic populations have yielded equivocal results. Further scientific-based knowledge is needed to clarify the ability of L-carnitine to improve exercise capacity and expedite the recovery process by reducing oxidative stress. This study aimed to examine the 9-week effects of L-carnitine supplementation on exercise performance, anaerobic capacity, and exercise-induced oxidative stress markers in resistance-trained males. [Methods] In a double-blind, randomized, and placebo-controlled treatment, 23 men (age, 25±2y; weight, 81.2±8.31 kg; body fat, 17.1±5.9%) ingested either a placebo (2 g/d, n=11) or L-carnitine (2 g/d, n=12) for 9 weeks in conjunction with resistance training. Primary outcome measurements were analyzed at baseline and at weeks 3, 6, and 9. Participants underwent a similar resistance training (4 d/w, upper/lower body split) for a 9-week period. Two-way ANOVA with repeated measures was used for statistical analysis. [Results] There were significant increases in bench press lifting volume at wk-6 (146 kg, 95% CI 21.1, 272) and wk-9 (245 kg, 95% CI 127, 362) with L-carnitine. A similar trend was observed for leg press. In the L-carnitine group, at wk-9, there were significant increases in mean power (63.4 W, 95% CI 32.0, 94.8) and peak power (239 W, 95% CI 86.6, 392), reduction in post-exercise blood lactate levels (-1.60 mmol/L, 95% CI -2.44, -0.75) and beneficial changes in total antioxidant capacity (0.18 mmol/L, 95% CI 0.07, 0.28). [Conclusion] L-carnitine supplementation enhances exercise performance while attenuating blood lactate and oxidative stress responses to resistance training.

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