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- 저자 : Hajime Tsuda (검색결과 2 건)
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Tsuda, Tohru,Morimoto, Yasuo,Yamato, Hiroshi,Fujino, Akihiro,Hori, Hajime,Kido, Masamitsu,Higashi, Toshiaki,Tanaka, Isamu 가톨릭대학교 산업의학센터 2001 韓國의 産業醫學 Vol.40 No.1
The primary concern of our study is to elucidate the development and pathophysiological mechanisms of occupational and environmental lung disease. The results of these studies are applied in the field of occupational health. Therefore, particular focuses are; 1) To introduce molecular-biomarkers into the risk assessment system of occupational exposed particles, 2) To apply molecular-biomarkers into conventional research methods, for the purpose of preventing and detecting early effects caused by occupational exposure to particles. Among fibrous materials, asbestos has been shown to cause diseases such as asbestosis, lung cancer and mesothelioma. On the other hand, there are many industries utilizing asbestos because of the many advantages as an industrial resource. The attempt to replace asbestos by man-made mineral fibres (MMFs) is fast in making progress because the industrial and economic gains are becoming certain. MMFs are thought to possess the same adverse biological effects as asbestos because of their similar physiochemical properties. Current data are now available showing that the new MMFs are not all nuisance particulate. No epidemiological studies are involving MMFs, and the results of animal studies on the adverse effects of MMFs are conflicting. Moreover, the toxic potentials of MMFs developed most are recently not always understood. Asia is a region which depends heavily on industrial development to sustain its growing population. Risk assessment of MMFs is a justifiable strategy to adopt particularly in this region. We have been constructing the risk assessment system of MMFs along following steps: study of physicochemical properties (1), in vitro study, intratracheal instillation study and acute to chronic inhalation study. We have compared the results of these steps with individual step and reached the final decision of toxicity to human. On the other hand, lung is one of the most important organ that is directly contact with the work environment. For this reason, factors concerning pathogenesis of occupational or work-related lung disease would be multiple. Thus, evaluating the environmental factors including smoking are also important.
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Clinical Presentation of Cervical Myelopathy at C1–2 Level
Yasutaka Murahashi,Tsuneo Takebayashi,Yoshinori Terashima,Hajime Tsuda,Mitsunori Yoshimoto,Toshihiko Yamashita 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.4
Study Design: Single-center retrospective study. Purpose: To clarify the clinical features of cervical myelopathy at the C1–2 level. Overview of Literature: Methods for distinguishing the affected level based on myelomere symptoms or dysfunction of the conducting pathway were established. However, no symptoms have been identified as being specific to the C1–2 level segment. Methods: We evaluated 24 patients with cervical myelopathy due to spinal cord compression at the C1–2 level. Preoperative neurological assessment were investigated and compared with the rate and site of compression of the spinal cord using computed tomography-myelography. Results: Impaired temperature and pain sensation were confirmed in 18 of the 24 patients with that localized to the upper arms (n=3), forearm (n=9), both (n=2), and whole body (n=4). Muscle weakness was observed in 18 patients, muscle weakness extended from the biceps brachii to the abductor digiti minimi in 10 patients, and in the whole body in 8 patients. Deep tendon reflexes were normal in 10 patients, whereas hyperactive deep tendon reflexes were noted in 14 patients. The rate of spinal cord compression was significantly higher in patients with perceptual dysfunction and muscle weakness compared with those with no dysfunction. However, no significant difference in the rate and site of compression was identified in those with dysfunction. Conclusions: Perceptual dysfunction and muscle weakness localized to the upper limbs was observed in 58% and 42% of patients, respectively. Neurological abnormalities, such as perceptual dysfunction and muscle weakness, were visualized in patients with marked compression.
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