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- 저자 : Ha Seunggyun (검색결과 5 건)
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Ha Seunggyun,O Joo Hyun,Park Chansoo,Boo Sun Ha,Yoo Ie Ryung,Moon Hyong Woo,Chi Dae Yoon,Lee Ji Youl 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.2
Objective: 177Lutetium [Lu] Ludotadipep is a novel prostate-specific membrane antigen targeting therapeutic agent with an albumin motif added to increase uptake in the tumors. We assessed the biodistribution and dosimetry of [177Lu]Ludotadipep in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods: Data from 25 patients (median age, 73 years; range, 60–90) with mCRPC from a phase I study with activity escalation design of single administration of [177Lu]Ludotadipep (1.85, 2.78, 3.70, 4.63, and 5.55 GBq) were assessed. Activity in the salivary glands, lungs, liver, kidneys, and spleen was estimated from whole-body scan and abdominal SPECT/CT images acquired at 2, 24, 48, 72, and 168 h after administration of [177Lu]Ludotadipep. Red marrow activity was calculated from blood samples obtained at 3, 10, 30, 60, and 180 min, and at 24, 48, and 72 h after administration. Organand tumor-based absorbed dose calculations were performed using IDAC-Dose 2.1. Results: Absorbed dose coefficient (mean ± standard deviation) of normal organs was 1.17 ± 0.81 Gy/GBq for salivary glands, 0.05 ± 0.02 Gy/GBq for lungs, 0.14 ± 0.06 Gy/GBq for liver, 0.77 ± 0.28 Gy/GBq for kidneys, 0.12 ± 0.06 Gy/GBq for spleen, and 0.07 ± 0.02 Gy/GBq for red marrow. The absorbed dose coefficient of the tumors was 10.43 ± 7.77 Gy/GBq. Conclusion: [177Lu]Ludotadipep is expected to be safe at the dose of 3.7 GBq times 6 cycles planned for a phase II clinical trial with kidneys and bone marrow being the critical organs, and shows a high tumor absorbed dose.
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Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies
Choi, Yoori,Ha, Seunggyun,Lee, Yun-Sang,Kim, Yun Kyung,Lee, Dong Soo,Kim, Dong Jin The Korea Society of Nuclear Medicine 2018 핵의학 분자영상 Vol.52 No.1
The pathological features of Alzheimer's disease are senile plaques which are aggregates of ${\beta}$-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer's disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer's disease.
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Kim, Yong-il,Ha, Seunggyun,So, Young,Lee, Won Woo,Byun, Seok-Soo,Kim, Sang Eun Springer Berlin Heidelberg 2014 EUROPEAN RADIOLOGY Vol.24 No.2
<P><B>Objective</B></P><P>We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates’ method) in a prospective study using Cr-51 EDTA GFR test as a gold standard.</P><P><B>Methods</B></P><P>Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis.</P><P><B>Results</B></P><P>The revised equation for improved GFR was GFR(mL/min) = (<I>%</I>renal uptake × 11.7773) − 0.7354. Gates’ original GFRs (70.1 ± 20.5 mL/min/1.73 m<SUP>2</SUP>) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m<SUP>2</SUP>; <I>P</I> < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m<SUP>2</SUP>) were not different from (<I>P</I> = 0.7360) and had a significant correlation with (<I>r</I> = 0.73, <I>P</I> < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (<I>n</I> = 25).</P><P><B>Conclusions</B></P><P>GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR.</P><P><B><I>Key Points</I></B></P><P>• <I>Measurement of glomerular filtration rate is difficult following nephrectomy</I>.</P><P>• <I>Measurements can be significantly improved by new renal sctintigraphic methods</I>.</P><P>• <I>This helps physicians to measure kidney function of patients following nephrectomy</I>.</P><P>• <I>Management of renal tumour patients should become more effective</I>.</P>
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Jung, Joo-Young,Cheon, Gi Jeong,Lee, Yun-Sang,Ha, Seunggyun,Chae, Mi-Hye,Chung, Yong-An,Yoon, Do Kyun,Bahk, Yong-Whee The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3
Purpose Currently, traumatic bone diseases are diagnosed by assessing the micro $^{99m}Tc$-hydroxymethylene diphosphonate (HDP) uptake in injured trabeculae with ongoing osteoneogenesis demonstrated by gamma correction pinhole scan (GCPS). However, the mathematic size quantification of micro-uptake is not yet available. We designed and performed this phantom-based study to set up an in-vitro model of the mathematical calculation of micro-uptake by the pixelized measurement. Methods The micro $^{99m}Tc$-HDP deposits used in this study were spontaneously formed both in a large standard flood and small house-made dish phantoms. The processing was as follows: first, phantoms were flooded with distilled water and $^{99m}Tc$-HDP was therein injected to induce micro $^{99m}Tc$-HDP deposition; second, the deposits were scanned using parallel-hole and pinhole collimator to generally survey $^{99m}Tc$-HDP deposition pattern; and third, the scans underwent gamma correction (GC) to discern individual deposits for size measurement. Results In original $na{\ddot{i}}ve$ scans, tracer distribution was simply nebulous in appearance and, hence, could not be measured. Impressively, however, GCPS could discern individual micro deposits so that they were calculated by pixelized measurement. Phantoms naturally formed micro $^{99m}Tc$-HDP deposits that are analogous to $^{99m}Tc$-HDP uptake on in-vivo bone scan. The smallest one we measured was 0.414 mm. Flooded phantoms and therein injected $^{99m}Tc$-HDP form nebulous micro $^{99m}Tc$-HDP deposits that are rendered discernible by GCPB and precisely calculable using pixelized measurement. Conclusions This method can be used for precise quantitative and qualitative diagnosis of bone and joint diseases at the trabecular level.
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