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RISS 인기검색어
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- 저자 : HASSAN ADELI (검색결과 3 건)
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HASSAN ADELI,SHARIF HUSSEIN SHARIF ZEIN,SOON HUAT TAN,ABDUL LATIF AHMAD 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.2
In this study the response surface methodology (RSM) coupled with the central composite design (CCD) were used to optimize the mechanical strength properties of poly(L-lactide)/multi-walled carbon nanotube (MWCNT) scaffolds. The scaffolds were prepared by the freeze-extraction method. MWCNTs were incorporated into PLLA composite as a reinforcement agent in order to improve the strength properties of the scaffolds. The effect of process parameters such as ratio of PLLA/(PLLA + MWCNT) (93–100%), solvent amount (100–200 ml), freezing time (5–7 h) and immersing time (2–4 days) were studied using the design of experiment (DOE). Based on CCD, quadratic model was obtained and developed to correlate the process parameters to the strength of the scaffolds. An analysis of variance (ANOVA) was applied to determine the significant factors affecting the experimental design response (strength) of the scaffolds. The predicted values after optimization process were in good agreement with the experimental values. The model was able to accurately predict the response of strength with less than 5% error.
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Alireza Joorabloo,Mohammad Taghi Khorasani,Hassan Adeli,Zohreh Mansoori-Moghadam,Armaghan Moghaddam 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-
This study aimed to optimize hydrogel wound dressings to achieve favorable properties of the watervapor transmission rate (WVTR) and proper degree of swelling ratio (DSR) to overcome the issues oftenassociated with most commercial dressings including improper breathability and insufficient exudateabsorption. Artificial neural network and response surface methodologies were utilized to design andmodel bionanocomposites. Besides, the effect of the ratio of components as input data, and WVTR andDSR properties as output (response) data were investigated. Hydrogel systems were produced via thefreeze–thaw method and were identified using infrared spectroscopy, dynamic light scattering, andscanning electron microscopy. To increase the antibacterial property of manufactured specimens, zincoxide nanoparticles were functionalized with heparin, and, other properties including mechanicalproperties, in vitro wound healing as well as toxicity analysis were investigated on the optimumformulation. Results showed an improvement in mechanical properties in the presence of nanoparticlesand also enhanced antibacterial property after conjugating heparin on nanoparticles. In vitro healing andcell viability results approved the biocompatibility and non-toxicity of the samples. Therefore,manufactured dressings were considered to have good DSR and WVTR, mechanical and biocompatibilityproperties and they exhibited good ability to heal and protect wounds.
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Alireza Joorabloo,Mohammad Taghi Khorasani,Hassan Adeli,Peiman Brouki Milan,Moein Amoupour 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
A study of many individual parameters is required to provide a robust investigation of a system inbiomedical applications. A comprehensive understanding of these parameters is achievable by an appropriateexperimental model as a valid description to predict the outputs (responses). A combination ofresponse surface methodology and artificial neural network has been employed to design hydrogel dressingsincluding polyvinyl alcohol, chitosan, and starch. The optimal ratio of components of hydrogels asinput data based on the water vapor transmission rate, gel content, swelling ratio, and porosity propertiesas output parameters was determined using the quick propagation algorithm. Zinc-oxide nanoparticleswere coupled with heparin and applied in the optimal formulation to investigate its effect on physicaland mechanical properties, cytotoxicity, and antibacterial activities as well as in vivo wound healing. Mechanical strength improved in the presence of zinc-oxide nanoparticles. Heparin release reached withthe saturation state in a longer period after conjugation onto zinc-oxide nanoparticles. Minimum inhibitoryconcentration decreased significantly by conjugation of heparin to the nanoparticles and current systemscould protect wounds against infections. In vivo wound healing and immunohistochemistry assayindicated accelerated wound closure, re-epithelialization, and skin regeneration for hydrogel dressingscontaining heparin functionalized zinc-oxide nanoparticles.
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