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Zhu Yifan,Xu Feng Xiang,Guan Yijie,Zou Zhen,Duan Libin,Du Zhanpeng,Ma Hongfeng 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.5
As an alternative to the conventional concave hexagonal honeycomb structure (CHHS), a negative Poisson’s ratio honeycomb structure with power function curve (NHPC) was devised. The relationship between the power function exponent (PFE) and normalized power function coefficient (NPFC) of honeycomb structure and its equivalent Poisson’s ratio (EPR) was explored to identify the range of variables required for the negative Poisson’s ratio effect. To investigate the in-plane mechanical properties and energy absorption characteristics of NHPC, the deformation mode, dynamic response, and energy absorption characteristics under various impact velocities were studied by constructing an in-plane impact simulation model. The results showed that NHPC obviously exhibited a negative Poisson’s ratio effect on medium and low impact velocities, and the deformation was primarily uniform. As the NPFC increased, the honeycomb structure was less prone to stress concentration, while the peak crushing force (PCF) and the specific energy absorption (SEA) declined and the plateau stress increased. A multi-objective optimization experiment was operated with low PCF and high SEA as the targets within the range of design variables in order to generate the optimal NHPC. According to the experimental findings, the improved NHPC showed a 25.48 % reduction in PCF and a 19.29 % increase in SEA. This paper provides theoretical recommendations for improving the energy absorption and structural optimization of the honeycomb structure.
1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization
Ghani, Lubna,Munk, Chastine F.,Zhang, Xiang,Katsube, Satoshi,Du, Yang,Cecchetti, Cristina,Huang, Weijiao,Bae, Hyoung Eun,Saouros, Savvas,Ehsan, Muhammad,Guan, Lan,Liu, Xiangyu,Loland, Claus J.,Kobilka American Chemical Society 2019 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.141 No.50
<P>Despite their major biological and pharmacological significance, the structural and functional study of membrane proteins remains a significant challenge. A main issue is the isolation of these proteins in a stable and functional state from native lipid membranes. Detergents are amphiphilic compounds widely used to extract membrane proteins from the native membranes and maintain them in a stable form during downstream analysis. However, due to limitations of conventional detergents, it is essential to develop novel amphiphiles with optimal properties for protein stability in order to advance membrane protein research. Here we designed and synthesized 1,3,5-triazine-cored dimaltoside amphiphiles derived from cyanuric chloride. By introducing variations in the alkyl chain linkage (ether/thioether) and an amine-functionalized diol linker (serinol/diethanolamine), we prepared two sets of 1,3,5-triazine-based detergents. When tested with several model membrane proteins, these agents showed remarkable efficacy in stabilizing three transporters and two G protein-coupled receptors. Detergent behavior substantially varied depending on the detergent structural variation, allowing us to explore detergent structure-property-efficacy relationships. The 1,3,5-triazine-based detergents introduced here have significant potential for membrane protein study as a consequence of their structural diversity and universal stabilization efficacy for several membrane proteins.</P> [FIG OMISSION]</BR>