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- 저자 : Gonza´lez-Ruiz, Carlos (검색결과 3 건)
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Agave tequilana Counteracts Chronic Hypertension and Associated Vascular Damage
Maribel Herrera-Ruiz,Zu´lima Jannette Gutie´rrez-Nava,Celeste Trejo-Moreno,Alejandro Zamilpa,Manase´s Gonza´lez-Cortazar,Antonio Ruperto Jime´nez-Aparicio,Enrique Jime´nez-Ferrer 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.4
Systemic arterial hypertension (SAH) is a health problem of great importance worldwide, and endothelial dysfunction underlies SAH development. This condition's main characteristics include vasoconstriction, inflammation, oxidative stress, and procoagulant and proliferative states. This study's objective was to evaluate the antihypertensive, anti-inflammatory, and antioxidant effects of the whole extract and fractions of Agave tequilana in a murine model of SAH. SAH was induced in male ICR or CD-1 (Strain obtained from animals from Charles River Laboratories, Massachusetts) mice by intraperitoneal administration of angiotensin II (AGII) (0.1 μg/kg) for 4 weeks, and then A. tequilana treatments were co-administered with AGII. At the end of the experiment, systolic and diastolic blood pressure were measured and the kidneys were dissected to quantify interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha, IL-10, and malondialdehyde (MDA). The whole extract and the fractions of A. tequilana were chemically characterized using gas chromatography-mass spectrometry. The results indicate that the whole extract (At-W) and At-AcOEt fraction treatment are the most efficient in lowering blood pressure, although all the treatments had an immunomodulatory effect on the cytokines evaluated and an antioxidant effect on lipid peroxidation. Finally, the chromatographic profile shows that the integral extract and fractions of A. tequilana contained phytol (M)3,7,11,15-Tetramethyl-2-hexadecen-1-ol; 9,12-octadecadienoic acid; hentriacontane; 9,19-cyclolanost-24-en-3-ol,(3b); t-sitosterol; and stigmasta-3,5-dien-7-one.
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Idalia Osuna-Ruiz,Marı´a Fernanda Espinoza-Marroquin,Jesu´ s Aaro´n Salazar-Leyva,Emyr Pen˜a,Carlos Alfonso A ´ lvarez-Gonza´lez,Isaura Ban˜uelos-Vargas,Emmanuel Martı´nez-Montan˜o 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.6
Pepsin from stomach of Bagre panamensis wassemi-purified and biochemically characterized. The acidproteolytic activity and purification fold were 3875 U/mgprotein and 91.85, respectively, after purification process. The optimum pH and temperature for semi-purified proteasewere 2–3 and 65 C, respectively. The enzymeactivity was stable after heating proteases at 50 C for120 min, but only 30% residual activity was detected afterheating at 65 C for 30 min. SDS-PAGE analysis showedtwo proteins bands after dialysis (26.1 and 38.6 kDa). Onlythe band of 38.6 kDa had proteolytic activity, which wasinhibited using pepstatin A. Organic solvents, surfactantsand reducing agents affect the proteolytic activity at differentextent; however, metal ions or EDTA have noimpact on protease activity. The semi-purified proteaseexhibited milk coagulant activity, with a maximum activityat 45 C. The obtained results highlight the potentialbiotechnological use of B. panamensis pepsin.
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Voice Recognition Systems Toward a Universal Language
Di´ez-Carrera, Carmen,Gonza´lez-Ruiz, Carlos Institute for University Language Sejong Instituti 2003 Journal of Universal Language Vol.4 No.2
An analysis of the major achievements of the last quarter of a century (means of transport and of communication, microelectronics, the conquest of Space, the globalisation of Society, computer networks, blocks of countries, the proliferation of International organisms and so on) would seem to suggest the need for a scientific study into the possibilities of a universal language. A real need exists, every day more pronounced and we consider that this is the right time for this investigation. As part of this project a discussion of possible alternative solutions is proposed (the use of a multi-lingual approach, English, multilingual intercompression, an international auxiliary language, "manufactured" languages, automatic translation, natural language, among others). There is also a definition of the theoretical specifications which this language should meet, taking into account all the current needs and the sectors involved (voice recognition, automatic translation, operative systems, programming languages, documentation, simple cross-cultural learning). The idea is based on a dual focus: person-to-person communication and person-to-machine communication. In order to achieve this double objective we shall select a set of universal sounds and phonemes which are common and understood by all people. The selection of this set of universal sounds and phonemes will e such that it will be easy to undertake a spectral discrimination. The phonetic, lexical and grammatical organization of the language will be established according to distinct levels of difficulty. Written forms will be expressed making use of the most appropriate phonetic transcription in each language. Design and development will be based on the Internet as a platform for investigation, cooperation and the consensus of hundreds of experts and a strategy is proposed for learning and spreading the language.
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