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RISS 인기검색어
- 검색키워드
- 저자 : Gicheru, M. (검색결과 4 건)
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( Mbuvi P Mutua ),( Lucilla Steinaa ),( Muya M Shadrack ),( Gicheru M Muita ) 한국동물자원과학회(구 한국축산학회) 2015 한국축산학회지 Vol.57 No.40
Background: Activation of peroxisome proliferator activated receptor gamma (PPAR γ) in the alveolar macrophages (AM) by selective synthetic PPAR γ ligands, improves the ability of the cells to resolve inflammation. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and show distinct functional differences from AM. The effects of treating FARM with PPAR γ ligands are unclear. Methods: FARM were harvested by lavage of chicken respiratory tract and their morphology assessed at microscopic level. The effects of PPAR γ agonists on the FARM in vitro viability, phagocytic capacity and proinflammatory cytokine (TNF-α) production were assessed. Results: FARM had eccentric nucleus and plasma membrane ruffled with filopodial extensions. Ultrastructurally, numerous vesicular bodies presumed to be lysosomes were present. FARM treated with troglitazone, a selective PPAR γ agonist, had similar in vitro viability with untreated FARM. However, treated FARM co-cultured with polystyrene particles, internalized more particles with a mean volume density of 41 % compared to that of untreated FARM of 21 %. Further, treated FARM significantly decreased LPS-induced TNF-α production in a dose dependent manner. Conclusion: Results from this study show that PPAR γ synthetic ligands enhance phagocytic ability of FARM. Further the ligands attenuate production of proinflammatory cytokines in the FARM, suggesting potential therapeutic application of PPAR γ ligands in the management of respiratory inflammatory disorders in the poultry industry.
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Mutua, Mbuvi P.,Steinaa, Lucilla,Shadrack, Muya M.,Muita, Gicheru M. Korean Society of Animal Science and Technology 2015 한국축산학회지 Vol.57 No.11
Background: Activation of peroxisome proliferator activated receptor gamma ($PPAR{\gamma}$) in the alveolar macrophages (AM) by selective synthetic $PPAR{\gamma}$ ligands, improves the ability of the cells to resolve inflammation. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and show distinct functional differences from AM. The effects of treating FARM with $PPAR{\gamma}$ ligands are unclear. Methods: FARM were harvested by lavage of chicken respiratory tract and their morphology assessed at microscopic level. The effects of $PPAR{\gamma}$ agonists on the FARM in vitro viability, phagocytic capacity and proinflammatory cytokine (TNF-${\alpha}$) production were assessed. Results: FARM had eccentric nucleus and plasma membrane ruffled with filopodial extensions. Ultrastructurally, numerous vesicular bodies presumed to be lysosomes were present. FARM treated with troglitazone, a selective $PPAR{\gamma}$ agonist, had similar in vitro viability with untreated FARM. However, treated FARM co-cultured with polystyrene particles, internalized more particles with a mean volume density of 41 % compared to that of untreated FARM of 21 %. Further, treated FARM significantly decreased LPS-induced TNF-${\alpha}$ production in a dose dependent manner. Conclusion: Results from this study show that $PPAR{\gamma}$ synthetic ligands enhance phagocytic ability of FARM. Further the ligands attenuate production of proinflammatory cytokines in the FARM, suggesting potential therapeutic application of $PPAR{\gamma}$ ligands in the management of respiratory inflammatory disorders in the poultry industry.
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Geoffrey K. KINUTHIA,Martha W. KIARIE-MAKARA,Michael M. GICHERU,Ephantus W. KABIRU,Dong-Kyu LEE 고신대학교 고신보건과학연구소 2010 보건과학연구소보 Vol.20 No.-
A cross sectional study was conducted in selected rural areas of Njoro, Kenya, to detennine the socio economic variables, poverty levels and disease control practices among the residents in 336 homesteads. The objective was to establish the relationship between parasitic diseases control practices, lifestyles and the poverty levels among the residents in the rural areas. In addition, a retrospective study involving recording of the frequency of parasitic and bacterial diseases diagnosed and treated in four randomly selected health centers, in the study area, from 2004 to 2009 was carried out. The results showed that the rural residents tend to have large families (68%), low education level (67%), high responsibility burden (67%) and a large number were living below poverty line (81%). The low economic status of residents coupled with certain lifestyles and practices pre-disposed the residents to infectious diseases. It was observed that'not boiling drinking water'had a higher probability of occurring among the lower economic cadre of residents than in medium economic cadre [Odds ratio (OR) = 2.36, 95% Confidence Interval (0) of 1.38 - 4.03]. Occurrences probability of 'not using a mosquito net'(OR = 1.44) and'not using a toilet paper always' (OR = 2.60) were higher in residents of low economic cadre. Retrospective survey showed that the malaria had a higher frequency (42.75%), followed by typhoid (24.14%), Entamoeba histolytica (20.83%), Giardia lamblia (20.32%), intestinal worms, Escherechia coli (3.35%) and Trichomonas hominis (1.63%). It was concluded that a combination of large family size, low education levels, high responsibility burdens, and low economic status contributed significantly to the occurrence of infectious health conditions in rural residents.
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