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- 저자 : Ghada Mohamed Taha (검색결과 2 건)
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Obesity may be erythropoietin dose-saving in hemodialysis patients
( Ghada M. El-kannishy ),( Abir F. Megahed ),( Mona M. Tawfik ),( Ghada El-said ),( Rabab T. Zakaria ),( Nahed A. Mohamed ),( Eman M. Taha ),( Alzhraa A. Ammar ),( Abeer M. Abd Eltawab ),( Nagy A. Say 대한신장학회 2018 Kidney Research and Clinical Practice Vol.37 No.2
Background: In dialysis patients, the obesity-survival paradox still requires an explanation. Anemia and high doses of erythropoiesis-stimulating agents (ESAs) are associated with worse outcomes in the hemodialysis (HD) population. In the present study, we explored the relation between obesity and anemia control in a sample of maintenance HD patients in Egypt. Methods: This multicenter observational study included 733 patients on maintenance HD from 9 hemodialysis centers in Egypt. Clinical and laboratory data as well as average doses of ESAs and parenteral iron were recorded. The erythropoietin resistance index (ERI) was calculated. Results: Obesity, defined as a body mass index (BMI) ≥ 30 kg/m<sup>2</sup>, was present in 22.6% of the studied population. The target hemoglobin level (10.0-11.5 g/dL) was achieved in 27.3% of non-obese and 25.3% of obese patients, with no significant difference. The median serum ferritin and the values of transferrin saturation index did not differ significantly between these two groups. The weekly ESA dose was significantly lower in obese than in non-obese patients (P = 0.0001). A trend toward higher ESA doses and ERI values was observed in patients with lower BMIs (P < 0.0001). Multiple linear regression revealed that the BMI and urea reduction ratio were the strongest predictors of the ERI. Conclusion: Our study adds more evidence to obesity-associated advantages in HD patients. BMI may determine ESA response, with better responses observed in patients with higher BMIs.
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Ali Hashem,Chukwunonso Onyeka Aniagor,Sayed Mohamed Badawy,Ghada Mohamed Taha 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.11
A novel biosorbent (‘Manna_COOH’) was synthesized via dual reaction stages of direct carbonylation of hydroxyl groups of richly cellulosic manna root powder and subsequent esterification of the resultant anhydride analogue into an ester of high carboxyl content. Both the biosorbent precursor and the 2,3-dihydroxybutanedioic acid sustain complementary features that ensured their efficient complexation. The biosorbent depicted a carboxyl content of 412.36 m.eq -COOH/100 g sample and was characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR). The study further evaluated the cobalt ion adsorption capacity of the synthesized ‘Manna_COOH’ under the effect of some process variable via batch mode. The Freundlich and pseudo-second-order models emerged as the best fit for the equilibrium and kinetic data, respectively. The rich oxygen-based surface functional groups entrenched on the ‘Manna_COOH’ sequel to its functionalization played a major role in making it a promising biosorbent for aqueous Co (II) uptake.
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