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- 저자 : Gao Qingtao (검색결과 2 건)
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Nodakenin Enhances Cognitive Function and Adult Hippocampal Neurogenesis in Mice.
Gao, Qingtao,Jeon, Se Jin,Jung, Hyun Ah,Lee, Hyung Eun,Park, Se Jin,Lee, Younghwan,Lee, Younghwa,Ko, Sang Yoon,Kim, Boseong,Choi, Jae Sue,Ryu, Jong Hoon Kluwer Academic/Plenum Publishers 2015 Neurochem Res Vol.40 No.7
<P>In our previous study, we demonstrated that nodakenin, a coumarin compound isolated from Angelica decursiva, ameliorates learning and memory impairments induced by scopolamine. In the present study, we investigated the effects of nodakenin on the cognitive function in the normal na?ve mice in a passive avoidance task, and the results showed that nodakenin significantly increased the latency time in normal na?ve mice. In addition, sub-chronic administration of nodakenin increased the number of 5-bromo-2-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus (DG) region. The percentage of BrdU and NeuN (neuronal cell marker)-immunopositive cells was also significantly increased by the nodakenin administration. Western blotting results showed that the expression levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β) were significantly increased in hippocampal tissue by sub-chronic nodakenin administration. These findings suggest that the sub-chronic administration of nodakenin enhances adult hippocampal neurogenesis in the DG region via Akt-GSK-3β signaling and this increase may be associated with nodakenin's positive effect on cognitive processing.</P>
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Jeon, Se Jin,Park, Ho Jae,Gao, Qingtao,Lee, Hyung Eun,Park, Se Jin,Hong, Eunyoung,Jang, Dae Sik,Shin, Chan Young,Cheong, Jae Hoon,Ryu, Jong Hoon Elsevier 2015 Behavioural brain research Vol.291 No.-
<P><B>Abstract</B></P> <P>Sleep loss, insomnia, is considered a sign of imbalance of physiological rhythm, which can be used as pre-clinic diagnosis of various neuropsychiatric disorders. The aim of the present study is to understand the pharmacological actions of α- or β-amyrin, natural triterpene compound, on the sleep in mice. To analyze the sleeping behavior, we used the well-known pentobarbital-induced sleeping model after single administration of either α- or β-amyrin. The sleeping onset time was remarkably decreased and duration was prolonged by β-amyrin (1, 3, or 10mg/kg) but not by α-amyrin (1, 3, or 10mg/kg). These effects were significantly blocked by GABA<SUB>A</SUB> receptor antagonist, bicuculline. Moreover, β-amyrin increased brain GABA level compared to the vehicle administration. Overall, the present study suggests that β-amyrin would enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pentobarbital-induced sleeping behavior was prolonged by β-amyrin. </LI> <LI> Increased sleeping behavior was blocked by GABA<SUB>A</SUB> receptor antagonist. </LI> <LI> Brain GABA level was increased by β-amyrin administration. </LI> </UL> </P>
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