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- 저자 : G. Lakshmi Vara Prasad (검색결과 2 건)
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G. Lakshmi Vara Prasad,Venkatagurunatham Naidu Kollu,M. Sailaja,S. Radhakrishnan,K. Jagan Mohan,A. Kishore Reddy,G. Rajesh Chandra 한국전기전자재료학회 2024 Transactions on Electrical and Electronic Material Vol.25 No.1
In this paper, we delve into the intriguing realm of Pseudo-morphic High Electron Mobility Transistors (pHEMTs) composed of InAs∕In0.3Al0.7As∕InSb∕In0.3Al0.7As layers, utilizing Silvaco-TCAD for simulation. Our focus centers on the assessment of RF and analog electrical characteristics, with a keen eye on the high-temperature eff ects. The influence of temperature on device performance is meticulously evaluated in comparison to a reference device operating at room temperature. Traditionally, the critical parameters such as threshold voltage ( Vth ), transconductance ( gm ), and Ion∕Ioff ratio have been calculated within the temperature range spanning from 300 K to 700 K. The primary pHEMT device in our study exhibits impressive attributes, featuring a drain current of 950 mA, a threshold voltage of -1.75 V, a high transconductance ( gm ) value of 650 mS/mm, an Ion∕Ioff ratio of 1 × 106 , a transition frequency ( ft ) soaring to 790 GHz, and a maximum frequency ( fmax ) reaching a staggering 1.4 THz. However, as we traverse the temperature spectrum, our findings unveil a compelling narrative. The impact of rising temperature is unequivocal, triggering a cascade of transformations within the device. Notably, as the temperature escalates, we observe a noticeable decrease in current, a reduction in transconductance ( gm ), and a diminishing Ion∕Ioff ratio. To unravel the intricacies of these temperature-induced effects, we introduce the infusion of Machine Learning (ML) into our analysis.
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Targeting autophagy in gastrointestinal malignancy by using nanomaterials as drug delivery systems
Raju, G. Seeta Rama,Pavitra, E.,Merchant, Neha,Lee, Hoomin,Prasad, Ganji Lakshmi Vara,Nagaraju, Ganji Purnachandra,Huh, Yun Suk,Han, Young-Kyu Elsevier 2018 Cancer letters Vol.419 No.-
<P><B>Abstract</B></P> <P>Autophagy is a conserved catabolic process involving large protein degradation by a ubiquitous autophagosomic signaling pathway, which is essential for cellular homeostasis. It is triggered by environmental factors such as stress, lack of nutrients, inflammation, and eliminating intracellular pathogens. Although the mechanisms underlying autophagy are still unclear, increasing evidence illuminates the magnitude of autophagy in a wide range of physiological processes and human diseases. Simultaneously, research community has focused on the triggering of autophagy by the internalization of engineered nanomaterials, which indicates a new line of revolution in cancer cure. However, most studies on nanoparticle-induced autophagy focus on brain, breast, and cervical cancers; limited reports are available on gastrointestinal (GI) cancers. Therefore, the aim of this mini review is to discuss in detail the role of autophagy in GI malignancy and the status of research on nanoparticle-induced autophagy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Role of autophagy in GI growth and metastasis. </LI> <LI> Autophagy as a new therapeutic target in GI malignancy. </LI> <LI> Use of nanoparticles as diagnostic and therapeutic agents in GI malignancy. </LI> <LI> Modulation of autophagy by nanoparticles as drug delivery carriers. </LI> </UL> </P>
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