http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ferdowshi, Zannatul (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Chowdhury, Mohammed Y.E.,Kim, Tae-Hwan,Uddin, Md Bashir,Kim, Jae-Hoon,Hewawaduge, C.Y.,Ferdowshi, Zannatul,Sung, Moon-Hee,Kim, Chul-Joong,Lee, Jong-Soo Elsevier 2017 Veterinary microbiology Vol.201 No.-
<P><B>Abstract</B></P> <P>To develop a safe and effective mucosal vaccine that broad cross protection against seasonal or emerging influenza A viruses, we generated a mucosal influenza vaccine system combining the highly conserved matrix protein-2 (sM2), fusion peptide of hemagglutinin (HA<SUB>2</SUB>), the well-known mucosal adjuvant cholera toxin subunit A1 (CTA1) and poly-γ-glutamic acid (γ-PGA)-chitosan nanoparticles (PC NPs), which are safe, natural materials that are able to target the mucosal membrane as a mucosal adjuvant. The mucosal administration of sM2HA2CTA1/PC NPs could induce a high degree of systemic immunity (IgG and IgA) at the site of inoculation as well as at remote locations and also significantly increase the levels of sM2- or HA2-specific cell-mediated immune response. In challenge tests in BALB/c mice with 10 MLD<SUB>50</SUB> of A/EM/Korea/W149/06(H5N1), A/Puerto Rico/8/34(H1N1), A/Aquatic bird/Korea/W81/2005(H5N2), A/Aquatic bird/Korea/W44/2005 (H7N3) or A/Chicken/Korea/116/2004(H9N2) viruses, the recombinant sM2HA2CTA1/PC NPs provided cross protection against divergent lethal influenza subtypes and also the protection was maintained up to six months after vaccination. Thus, sM2HA2CTA1/PC NPs could be a promising strategy for a universal influenza vaccine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Construction of poly-γ-glutamic acid (γ-PGA)-chitosan nanoparticles (PC NPs) containing conserved antigens of Influenza virus and mucosal adjuvant cholera toxin subunit A1 (CTA1) as a safe and effective mucosal vaccine against emerging influenza A viruses. </LI> <LI> The mucosal administration of sM2HA2CTA1/PC NPs could induce a high degree of systemic, mucosal and cell-mediated immune response. </LI> <LI> Induced immune responses could protect mice against 10MLD<SUB>50</SUB> of divergent influenza subtypes. </LI> <LI> The immune response and efficacy of protection was maintained up to six months after final inoculation. </LI> </UL> </P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
