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Jing Ma,Suhe Dong,Hongtao Lu,Zhongmin Chen,Huijie Yu,Xuejun Sun,Renjun Peng,Wei Li,Sinian Wang,Qisheng Jiang,Fengsheng Li,Li Ma 한국생체재료학회 2022 생체재료학회지 Vol.26 No.2
Objective: This study aimed to reveal the protective effect of hydrogen storage nanomaterial MgH2 on radiationinduced male fertility impairment. Methods: The characterization of MgH2 were analyzed by scanning electron microscopy (SEM) and particle size analyzer. The safety of MgH2 were evaluated in vivo and in vitro. The radioprotective effect of MgH2 on the reproductive system were analyzed in mice, including sperm quality, genetic effect, spermatogenesis, and hormone secretion. ESR, flow cytometry and western blotting assay were used to reveal the underlying mechanisms. Results: MgH2 had an irregular spherical morphology and a particle size of approximately 463.2 nm, and the content of Mg reached 71.46%. MgH2 was safe and nontoxic in mice and cells. After irradiation, MgH2 treatment significantly protected testicular structure, increased sperm density, improved sperm motility, reduced deformity rates, and reduced the genetic toxicity. Particularly, the sperm motility were consistent with those in MH mice and human semen samples. Furthermore, MgH2 treatment could maintain hormone secretion and testicular spermatogenesis, especially the generation of Sertoli cells, spermatogonia and round sperm cells. In vitro, MgH2 eliminated the [·OH], suppressed the irradiation-induced increase in ROS production, and effectively alleviated the increase in MDA contents. Moreover, MgH2 significantly ameliorated apoptosis in testes and cells and reversed the G2/M phase cell cycle arrest induced by irradiation. In addition, MgH2 inhibited the activation of radiation-induced inflammation and pyroptosis. Conclusion: MgH2 improved irradiation-induced male fertility impairment by eliminating hydroxyl free radicals.
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QIANG WANG,Fengsheng Qi,Fang Wang,Baokuan Li 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
A transient three-dimensional (3D) model is developed for understanding the electromagnetism, heat transfer and phase change in electroslag remelting (ESR) furnace with triple-electrode. The electromagnetic fields are solved by Maxwell’s equations using the finite element method. The temperature field and phase change are modeled by the enthalpy approach. A reasonable agreement is obtained between experiment and simulation. The electric current flows from one electrode into the slag and comes out from other two electrodes. Most electric current travels through the slag near the slag/ingot interface. A great amount of the Joule heating is generated by the slag and a higher value is found in the slag around the three electrodes. The highest temperature is located at the center of the slag layer. Increase in the current causes the increase in the Joule heating. A hotter slag and a deeper metal pool therefore are formed. The total Joule heating in the slag increases with more slag, while the average Joule heating density reduces. The metal pool depth increases and then decreases with the increasing slag thickness, and the deepest metal pool is obtained at the slag thickness of 200 mm. The power efficiency and the slag temperature reduce with the increasing electrode immersion depth. A shallower electrode immersion depth is a better choice for the ESR process with triple-electrode.
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