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- 저자 : Farshad Qalekhani (검색결과 1 건)
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Azam Chahardoli,Farshad Qalekhani,Yalda Shokoohinia,Ali Fattahi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
Titanium dioxide nanoparticles (TiO2NPs) were produced using a crud flavonoid luteolin (LT) by the greenprocess. Physicochemical characterizations of LT mediated synthesis of TiO2NPs (LT-TiO2NPs) were analyzedby different techniques. The biocompatibility of LT-TiO2NPs was evaluated by assessing their cytotoxicity,inhibition of protein denaturation, hemolysis effects, and membrane stabilization activity. Thesynthesized LT-TiO2NPs exhibited mostly rod-shaped morphology, rutile crystalline structure with lengthabout 33.3–135 nm and width in 16.6–58 nm. Under LT-TiO2NPs treatments, the cell viability of cancercells was decreased in a dose-dependent manner. According to the results, the IC50 values of LT-TiO2NPswere between 12.5–25 lg/mL for A375 and MCF-7 cancer cells, and its value was below 50 lg/mL for skinfibroblast. These NPs also induced intracellular reactive oxygen species (ROS) generation and causedmitochondrial disruption in cancer cells, leading to the induction of intrinsic apoptosis. These biosynthesizedNPs did not show denaturation of bovine serum albumin (BSA) protein and hemolytic or heatinducedhemolytic effects, which confirmed their membrane stabilization activity without damagingred blood cells (RBCs) membrane integrity. Therefore, this research provides valuable results in the caseof green synthesis of LT-TiO2NPs and their specific properties, biocompatibility, and their potential to beused in biomedical fields.
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