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- 저자 : Fangqiu Wang (검색결과 2 건)
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Joint Estimation of TOA and DOA in IR-UWB System Using Sparse Representation Framework
Fangqiu Wang,Xiaofei Zhang 한국전자통신연구원 2014 ETRI Journal Vol.36 No.3
This paper addresses the problem of joint time of arrival(TOA) and direction of arrival (DOA) estimation inimpulse radio ultra-wideband systems with a two-antennareceiver and links the joint estimation of TOA and DOA tothe sparse representation framework. Exploiting this link,an orthogonal matching pursuit algorithm is used forTOA estimation in the two antennas, and then the DOAparameters are estimated via the difference in the TOAsbetween the two antennas. The proposed algorithm canwork well with a single measurement vector and can pairTOA and DOA parameters. Furthermore, it has betterparameter-estimation performance than traditionalpropagator methods, such as, estimation of signalparameters via rotational invariance techniquesalgorithms matrix pencil algorithms, and other new jointestimationschemes, with one single snapshot. Thesimulation results verify the usefulness of the proposedalgorithm.
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( Chun-Jen Liu ),( Wan-Long Chuang ),( I-Shyan Sheen ),( Horng-Yuan Wang ),( Chi-Yi Chen ),( Kuo-Chih Tseng ),( Ting-Tsung Chang ),( Benede tta Massetto ),( Jenny Yang ),( Gregory Camus ),( Fangqiu Zh 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Patients co-infected with HCV and HBV have more rapid progression and worse outcomes than mono-infected patients. Taiwan has among the highest prevalence of chronic HCV/HBV coinfection in Southeast Asia. This study evaluated the safety and efficacy of an all-oral treatment with ledipasvir(LDV)/sofosbuvir(SOF) for 12 weeks in chronic HCV and HBV coinfection. Methods: Patients with or without compensated cirrhosis chronic HCV GT1/GT2 and HBV (HBsAg+) treatment naïve were enrolled into open-label, receiving LDV 90 mg/SOF 400 mg(QD) for 12 weeks. The primary efficacy endpoint is SVR12. HBV DNA was monitored at all study visits and it will be monitored for 2 years post-treatment. Results: A total of 111 patients (68[61%] with GT1 and 43[39%] with GT2) were enrolled and treated. The majority were female(62%), treatment naive(67%), and non-cirrhotic(85%), with a mean age of 55 years and mean BMI of 24.5kg/m2. All but one was HBeAg negative. Mean baseline HBV DNA was 2.1 log10IU/mL. SVR4 was 100%(111/111). The mean change in HBV DNA ranged from -0.06 log10IU/mL at week 1 to +0.49 log10IU/mL at follow-up visit 4; HBV DNA kinetics are shown in Fig 1. 60(54%) patients had an increase in HBV DNA> 10 x BL or became HBV DNA > LLOQ. No patients had ALT ≥ 2 X baseline. No patients discontinued treatment due to adverse events (AEs). Three patients had serious AEs(optic neuritis, post procedural bleeding and duodenal ulcer bleeding; none was considered drug related). Conclusions: In chronic HCV/HBV infection patients, LDV/SOF for 12 weeks resulted in an SVR4 rate of 100%. Although most patients had an increase in HBV DNA during treatment, this was not associated with ALT elevations ≥2 X baseline, and no patients started HBV therapy to date. This all-oral, interferon-free regimen was well tolerated, supporting its potential as a treatment option for HCV/HBV co-infected patients.
ScienceON
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