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Synthesis, Antioxidant and Antimicrobial Evaluation of Simple Aromatic Esters of Ferulic Acid
Burcu Çaliskan Ergün,Erden Banoglu,Tülay Çoban,Fatma Kaynak Onurdag 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
Aromatic ester derivatives of ferulic acid where the phenolic hydroxyl is free (6a-d) or acetylated (5a-d) were evaluated for their antioxidant and antimicrobial properties. The superoxide radical scavenging capacity of compounds 5d and 6d-e (IC_50 of 0.19, 0.27 and 0.20 mM, respectively)was found to be twice as active as α-tocopherol (IC_50 = 0.51 mM). DPPH radical scavenging capacity was moderate and only found in compounds bearing free phenolic hydroxyl groups (6a-e). With regard to antimicrobial properties, compounds 6b and 6c displayed significant activity against Enterococcus faecalis (MICs = 16 μg/mL) and vancomycin-resistant E. faecalis (MIC for 6b, 32 and for 6c, 16 μg/mL). Compound 6c also demonstrated prominent activity against planktonic Staphylococcus aureus with a MIC value of <8 μg/mL and it inhibited bacterial biofilm formation by S. aureus with a MBEC value of <8 μg/mL, which was 64 and 128 times more potent than ofloxacin and vancomycin, respectively.
Sukuroglu, Murat,Caliskanergun, Burcu,Unlu, Serdar,Sahin, M.Fethi,Kupeli, Esra,Yesilada, Erdem,Banoglu, Erden The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analygesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.
Murat SÜKÜROGLU,Burcu ÇALISKAN ERGÜN,Serdar ?L?,M. Fethi SAHIN,Esra K?ELI,Erdem YESILADA,Erden BANOGLU 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.5
A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)- 3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenaninduced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.