Measurement of Contrast Sensitivity in Patients with Behçet’s Disease without Ocular Involvement

Ercan Ozsoy,Cem Cankaya,Emrah Ozturk,Abuzer Gunduz,Pamuk Betul Ulucan 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate contrast sensitivity in patients with Behçet’s disease (BD) without ocular involvement. Methods: The study group was composed of 47 BD patients (20 to 50 years of age) who did not have ocular involvement. The control group was composed of 47 normal volunteers who were similar to the study group in terms of age and gender. No participants in this study had any ocular or systemic pathologies except for BD. The contrast sensitivity measurements were performed using the Functional Acuity Contrast Test under photopic conditions, and the results were compared between the two groups. Results: The mean age of the BD patients and control subjects was 34.5 ± 9.7 and 33.2 ± 7.6 years, respectively. The mean disease duration of the BD patients was 5.5 ± 6.4 years. There was a statistically significant decrease at five spatial frequencies (A, 1.5; B, 3; C, 6; D, 2; and E, 18 cycles per degree) in patients with BD compared with control subjects (p < 0.001, p = 0.004, p = 0.002, p < 0.001, and p = 0.001, respectively). Conclusions: The contrast sensitivity of BD patients without ocular involvement was lower than that of the control group. Further studies seem mandatory to confirm our results.

Measurement of Contrast Sensitivity in Patients with Behçet’s Disease without Ocular Involvement

Ercan Ozsoy 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate contrast sensitivity in patients with Behçet’s disease (BD) without ocular involvement. Methods: The study group was composed of 47 BD patients (20 to 50 years of age) who did not have ocularinvolvement. The control group was composed of 47 normal volunteers who were similar to the study group interms of age and gender. No participants in this study had any ocular or systemic pathologies except for BD. The contrast sensitivity measurements were performed using the Functional Acuity Contrast Test under photopicconditions, and the results were compared between the two groups. Results: The mean age of the BD patients and control subjects was 34.5 ± 9.7 and 33.2 ± 7.6 years, respectively. The mean disease duration of the BD patients was 5.5 ± 6.4 years. There was a statistically significantdecrease at five spatial frequencies (A, 1.5; B, 3; C, 6; D, 2; and E, 18 cycles per degree) in patients with BDcompared with control subjects (p < 0.001, p = 0.004, p = 0.002, p < 0.001, and p = 0.001, respectively). Conclusions: The contrast sensitivity of BD patients without ocular involvement was lower than that of the controlgroup. Further studies seem mandatory to confirm our results.

Serum Cystatin C Concentrations in Patients with Graves’ Ophthalmopathy

Nagehan Can,Ercan Ozsoy,Sabiha Gungor Kobat,Elif Yusufoglu,Nevin Ilhan,Tamer Demir 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.5

Purpose: To evaluate the concentration of serum cystatin C (CysC) in patients with Graves’ ophthalmopathy (GO) and the usabilityof the serum CysC concentrations in the follow-up of the disease. Methods: Thirty patients with GO and 30 healthy age-matched volunteers were included in this cross-sectional study. GOwas diagnosed based on the European Group on Graves’ Orbitopathy consensus. Serum thyroid-stimulating hormone, freetriiodothyronine, free thyroxine, and CysC concentrations were measured in the participants. The serum CysC concentrationswere compared between patients with GO and controls. Patients with GO were subdivided into hyperthyroid and euthyroidpatients, and their serum CysC concentrations were compared. In addition, the CysC concentrations in hyperthyroid and euthyroidpatients with GO were compared separately with those of healthy subjects. Kruskal-Wallis test and Student’s t-testwere used for statistical evaluation. Results: The mean serum CysC concentrations in GO patients and controls were 1.04 ± 0.36 and 0.74 ± 0.09 mg/L, respectively. There was a statistically significant difference in the serum CysC concentrations between patients with GO and control subjects (p< 0.001). Fifteen patients had hyperthyroid status, and 15 patients had euthyroid status. The mean serum CysC concentrationsin hyperthyroid and euthyroid patients with GO were 1.35 ± 0.22 and 0.72 ± 0.13 mg/L, respectively. Serum CysC concentrationswere significantly higher in hyperthyroid patients than in euthyroid patients (p = 0.001). In addition, hyperthyroid patients hadsignificantly higher serum CysC concentrations than healthy subjects. Among patients with GO, 21 and nine had mild and moderate-to-severe GO, respectively. Active and inactive GO were observed in eight and 22 patients, respectively. Conclusions: The serum CysC concentrations in hyperthyroid patients were higher than those in healthy subjects. Moreover,hyperthyroid patients had higher serum CysC concentrations than euthyroid patients. Further studies with a larger samplesize are needed to confirm these results.

Evaluation of Metabolite Changes in the Occipital Cortex of Patients with Idiopathic Infantile Nystagmus or Bilateral Ametropic Amblyopia by Magnetic Resonance Spectroscopy

Ismail Konus,Ercan Ozsoy,Peykan Turkcuoglu,Sinan Emre,Fulya Duman 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.5

Purpose: To evaluate the effects of idiopathic infantile nystagmus (IN) and bilateral ametropic amblyopia on metabolitesin the occipital cortex by magnetic resonance spectroscopy. Methods: The children included in this prospective study were divided into three groups. Group 1 consisted of11 patients with idiopathic IN, group 2 consisted of 10 patients with bilateral ametropic amblyopia and group3 consisted of nine normal children. A single-voxel magnetic resonance spectroscopy examination was performedby placing a region of interest on the occipital cortex of each participant. N-acetyl aspartate (NAA),creatine (Cr) and choline (Cho) concentrations were measured in the occipital cortex. This was followed bycalculating and comparing the NAA/Cr and Cho/Cr ratios between the three groups. The Kruskal-Wallis test,Mann-Whitney U-test, and chi-square test were used for statistical analysis. Results: There was no statistically significant difference in NAA/Cr ratios between patients with idiopathic INand normal children, but there was a statistically significant difference between these groups when Cho/Crratios were compared; the ratio was higher in the idiopathic IN group. There were no statistically significant differencesin NAA/Cr or Cho/Cr ratios between patients with bilateral ametropic amblyopia and normal children. Conclusions: Our findings suggest that the neurochemical profile of the occipital cortex is partially affected byidiopathic IN, but not by bilateral ametropic amblyopia.

Application of Rhenium-186 Radiosynovectomy in Elbow Diffuse Pigmented Villonodular Synovitis: Case Report with Multiple Joint Involvement

Koca, Gokhan,Ozsoy, Hakan,Atilgan, Hasan Ikbal,Demirel, Koray,Dincel, Veysel Ercan,Korkmaz, Meliha The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.3

After surgical therapy of diffuse pigmented villonodular synovitis (DPVNS), recurrence is seen in almost half of the patients. The effectiveness of radiosynovectomy (RSV) in preventing recurrence and complaints of DPVNS is well known. Elbow involvement in DPVNS is a very rare condition; therefore, RSV in elbow hasn't been experienced widely. The aim of this case report is to show the effectiveness of RSV with rhenium-186 (Re-186) sulfide colloid. We applied Re-186 sulfide colloid to the elbow joint of DPVNS patients six weeks after arthroscopic synovectomy. As a result, the patient did not have any complaints, and our findings are compatible with residue or recurrence on magnetic resonance imaging (MRI) in sixth and twentieth month controls after administration. We concluded that Re-186 is an effective adjuvant therapy for the prevention of recurrence and complaints.