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EOH, Jae-Hyuk,NO, Hee Cheon,YOO, Yong-Hwan,JEONG, Ji-Young,KIM, Jong-Man,KIM, Seong-O Atomic Energy Society of Japan 2010 Journal of nuclear science and technology Vol.47 No.11
<P>For a CO<SUB>2</SUB> ingress accident into liquid sodium in a supercritical CO<SUB>2</SUB> power conversion system coupled with a sodium-cooled fast reactor, we investigated two major design issues: i) a wastage phenomenon in regard to structural damage adjacent to the leaking position, and ii) potential channel plugging due to the formation of a particulate reaction product. In order to understand the factors affecting the occurrence of these issues, two kinds of experiments were carried out: a wastage effect test and a self-plugging test. All experimental conditions were chosen to reasonably represent the normal operating conditions and realistic design parameters of the reference plant. The test results indicate the absence of wastage, which will not lead to additional tube ruptures and damage propagation. In the current experiment, the self-plugging of PCHE channels only took place under two limited conditions: i) the sodium temperature is over 500°C and ii) the equivalent diameter of the crack opening is less than 1.5 mm with a small leakage rate of far less than 1 g/s of CO<SUB>2</SUB> ingress.</P>
Eoh, Kyung Jin,Paek, Jiheum,Kim, Sang Wun,Kim, Hee Jung,Lee, Hye Yeon,Lee, Sang Kil,Kim, Young Tae NATIONAL HELLENIC RESEARCH FOUNDATION 2017 Oncology Reports Vol.38 No.6
<P>Contemporary research has focused on the function of long non-coding RNAs (lncRNAs) in carcinogenesis. However, the involvement of the lncRNA, steroid receptor RNA activator (SRA), in cervical carcinogenesis remains to be elucidated. In the present study, we investigated the bio-functional consequences of lncRNA SRA knockdown <I>in vitro</I>. To verify the role of lncRNA SRA in cell proliferation, migration, and invasion, lncRNA RNA interference was utilized to knock down lncRNA SRA expression in cervical cancer cell lines, resulting in our discovery that lncRNA SRA knockdown inhibited cell proliferation, cell migration and tumor invasion in the cervical cancer cell lines. Additionally, <I>in vitro</I> experiments using the lncRNA SRA-knockdown cervical cancer cell lines revealed that lncRNA SRA is a strong inducer and modulator of the expression of genes related to epithelial-mesenchymal transition and the NOTCH signaling pathway. In conclusion, our findings demonstrated that lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. Furthermore, these results indicate that lncRNA SRA may be a potential therapeutic target and prognostic marker for cervical malignancy.</P>
Eoh, Hyungjin,Jeon, Bo-Young,Kim, Zhiyeol,Kim, Seung-Cheol,Cho, Sang-Nae AAVLD 2010 Journal of veterinary diagnostic investigation Vol.22 No.4
<P>Brucella abortus is a bacterium of brucellosis causing abortion in cattle. The diagnosis of bovine brucellosis mainly relies on serologic tests using smooth lipopolysaccharide (S-LPS) from B. abortus. However, the usefulness of this method is limited by false-positive reactions due to cross-reaction with other Gram-negative bacteria. In the present study, the eryC gene encoding B. abortus d-erythrulose 1-phosphate dehydrogenase, which is involved in the erythritol metabolism in virulent B. abortus strain but is absent from a B. abortus vaccine strain (S19), was cloned. Recombinant EryC was expressed and purified for the evaluation as a diagnostic reagent for bovine brucellosis. Other B. abortus proteins, Omp16, PP26, and CP39 were also purified and their seroreactivities were compared. Recombinant EryC, Omp16, PP26, and PP39 were all reactive to B. abortus-positive serum. The specificity of recombinant Omp16, PP26, CP39, and EryC, were shown to be approximately 98%, whereas that of B. abortus whole cell lysates was shown to be 95%. The sensitivity of Omp16, PP26, CP39, and EryC were 10%, 51%, 64%, and 43%, respectively, whereas that of B. abortus whole cell lysates was 53%. These results suggested that B. abortus EryC would be a potential reagent for diagnosis for bovine brucellosis as a single protein antigen.</P>
Eoh, Jae-Hyuk,Park, Shane,Jeun, Gyoo-Dong,Kim, Moo-Hwan Korean Nuclear Society 2001 Nuclear Engineering and Technology Vol.33 No.2
Under severe accidents, the pressure and temperature response has an important role for the integrity of a nuclear power plant containment. The history of the pressure and temperature is characterized by the amount and state of steam/air mixture in a containment. Recently, the heat transfer rate to the structure surface is supposed to be increased by the wavy interface formed on condensate film. However, in the calculation by using CONTAIN code, the condensation heat transfer on a containment wall is calculated by assuming the smooth interface and has a tendency to be underestimated for safety. In order to obtain the best- estimate heat transfer calculation, we investigated the condensation heat transfer model in CONTAIN 1.2 code and adopted the new forced convection correlation which is considering wavy interface. By using the film tracking model in CONTAIN 1.2 code, the condensate film is treated to consider the effect of wavy interface. And also, it was carried out to investigate the effect of the different cell modelings - 5-cell and 10-cell modeling - for KNGR(Korean Next Generation Reactor) containment phenomena during a severe accident. The effect of wavy interface on condensate film appears to cause the decrease of peak temperature and pressure response . In order to obtain more adequate results, the proper cell modeling was required to consider the proper flow of steam/air mixture.
Eoh, Kyung Jin,Lee, So Hyun,Kim, Hee Jung,Lee, Jung-Yun,Kim, Sunghoon,Kim, Sang Wun,Kim, Young Tae,Nam, Eun Ji Elsevier 2018 Biochemical and biophysical research communication Vol.497 No.2
<P><B>Abstract</B></P> <P>MicroRNA-630 (miR-630) has been implicated in the development and progression of multiple cancers. The current study aimed to investigate the role of miR-630 in chemoresistant epithelial ovarian cancer. MiR-630 expression levels were detected in ovarian cancer cell line SKOV3 and paclitaxel-resistant SKOV3 (SKOV3-TR) via microarray and qRT-PCR. MiR-630 inhibitors and negative controls were transfected into SKOV3 and SKOV3-TR cells. Wound healing, invasion, chemosensitivity, and cell apoptosis assays were performed to determine proliferation and migration rates. Chemoresistant patient-derived xenograft (PDX) models were established and utilized to verify the effect of miR-630 on chemoresistant ovarian cancer. Inhibition of miR-630 decreased cell proliferation and enhanced the sensitivity of SKOV3-TR and SKOV3 cells to paclitaxel. In the chemosensitivity assay, we observed that the miR-630 inhibitor exhibited a synergistic effect with paclitaxel on SKOV3-TR cells. Inhibition was correlated with enhanced expression of apoptosis-related proteins. APAF-1 was predicted to be a potential target of miR-630. An <I>in vivo</I> PDX study showed that the miR-630 inhibitor sensitized chemoresistant ovarian cancer to paclitaxel. Thus, miR-630 inhibitor sensitizes chemoresistant epithelial ovarian cancer to chemotherapy by enhancing apoptosis. Our findings suggest that miR-630 might be a potential therapeutic target for chemotherapy-resistant ovarian cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We investigated the role of miR-630 in chemoresistant epithelial ovarian cancer. </LI> <LI> MiR-630 inhibition reduced proliferation and enhanced chemosensitivity <I>in vitro.</I> </LI> <LI> Inhibition was correlated with enhanced expression of apoptosis-related proteins. </LI> <LI> APAF-1 was predicted to be a potential target of miR-630. </LI> <LI> Inhibition sensitized chemoresistant ovarian cancer to paclitaxel <I>in vivo.</I> </LI> </UL> </P>