http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : En-Tao Wu (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
En-Tao Wu,Ming-Bo Qiu,Zong-Xiu Yao,Jing-Tao Li,Yi-Miao Zhang 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.5
Square holes are characterized by high torque and good guidance. They are widely used in various industries, including aviation, aerospace, automobiles, and molding. In this study, a step-by-step electrical discharge machining (SSP) method was used to investigate the precision machining of square blind holes in a titanium alloy. This method integrates a limited set of multiple machining strategies with electrical discharge machining (EDM) by utilizing small shaped formed electrodes and step-by-step feeding for EDM. The main objective of this study was to investigate the machining efficiency and the surface quality of square blind holes in a titanium alloy. Two methods, EDM and SSP, were used to produce roughened circular pre-drilled components and square hole samples. Compared to EDM, SSP met the machining requirements of the square blind hole and improved machining efficiency by over three times, as well as surface quality by 16.06%. Subsequently, the influence of the machining area on precision machining was investigated, and a step-by-step precision machining process was established. Finally, two SSP methods, namely one-time SSP (O-SSP) and multiple SSP (M-SSP), were used for precision machining of rough-machined samples. Compared to O-SSP, M-SSP achieved higher machining accuracy and surface quality, despite its lower machining efficiency. The square hole, with a depth of 25 mm, was refined using M-SSP. It exhibited an upper and lower taper of 0.02 mm, a minimum fillet radius of R 0.04 mm, and a bottom corner radius of R 0.127 mm.
-
In Vivo Evaluation of Curcumin-loaded Nanoparticles in a A549 Xenograft Mice Model
Yin, Hai-Tao,Zhang, De-Geng,Wu, Xiao-Li,Huang, Xin-En,Chen, Gang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Curcumin (Cum) has been reported to have potential chemo-preventive and chemotherapeutic activity through influencing various processes, inducing cell cycle arrest, differentiation and apoptosis in a series of cancers. However, the poor solubility of Cum limits its further applications in the treatment of cancer. We have previously reported Cum-loaded nanoparticles (Cum-NPs) prepared with amphilic methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers. The current study demonstrated superior antitumor efficacy of Cum-NPs over free Cum in the treatment of lung cancer. In vivo evaluation further demonstrated superior anticancer effects of Cum-NPs by delaying tumor growth compared to free Cum in an established A549 transplanted mice model. Moreover, Cum-NPs showed little toxicity to normal tissues including bone marrow, liver and kidney at a therapeutic dose. These results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen. They thus merit more research to evaluate the feasibility of clinical application.
-
In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment
Hou, Zhi-Bo,Lu, Kai-Jin,Wu, Xiao-Li,Chen, Cong,Huang, Xin-En,Yin, Hai-Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
