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RISS 인기검색어
- 검색키워드
- 저자 : Elumalai Nandhakumar (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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In vitro Antioxidant Activities of Methanol and Aqueous Extract of Annona squamosa (L.) Fruit Pulp
Elumalai Nandhakumar,Parameswaran Indumathi 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.3
The present study evaluated the antioxidant activity of the fruit of Annona squamosa by means of in vitro studies involving two different solvent extracts: methanol and aqueous. The antioxidant properties of the extract were determined by scavenging 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), lipid peroxidation (LPO), nitric oxide (NO), superoxide anion (O₂-), hydroxyl radical (OHㆍ), reducing power and total antioxidant. The results showed that, compared to aqueous extract, a methanolic fruit extract of A squamosa has a higher percentage of inhibition of DPPH radical scavenging activity (97.99%), LPO (94.15%), NO scavenging activity (70.96%), O₂- scavenging activity and OHㆍ scavenging activity (78.68% and 85.25%, respectively), total antioxidant activity (206 µg α-tocopherol/g) and reducing power (56.0 µg of ascorbic acid/g). The results obtained in the in vitro models clearly suggest that methanol extract has higher antioxidant activity than the aqueous extract due to a higher presence of phenolic and flavonodal constituents in the methanol extract.
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Elumalai Nandhakumar,Ayyakkannu Purushothaman,Panchanadham Sachdanandam 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
Shemamruthaa (SM), an indigenous herbalformulation (Hibiscus rosa sinensis flowers, Phyllanthusemblica, and pure honey) in a definite ratio was analyzedusing acute and sub-acute toxicity studies in Sprague-Dawley rats. The acute toxicity study for 72 h showed noadverse effects in behavior or mortality at a dosage of 75-2,000 mg/kg of BW. The sub-acute toxicity study at 50,100, 250, and 500 mg/kg of BW for 30 days showedtransient rises in the white blood cell count, and levels ofhemoglobin, free fatty acids, high density lipoproteins, andcholesterol, and a significant decrease in the blood glucose,cholesterol, triglyceride, phospholipid, and LDL levels. Other parameters remained unchanged. Changes observedwere significant only at the highest dosage of 500 mg/kgBW. These results proved that the drug SM is safe and nottoxic.
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