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- 저자 : Eliana Aparecida Varanda (검색결과 2 건)
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Katiuska Tuttis,Daryne Lu Maldonado Gomes da Costa,Juliana Mara Serpeloni,Lourdes Campaner dos Santos,Eliana Aparecida Varanda,Wagner Vilegas,Wilner Martınez-Lopez,Ilce Mara de Syllos Cólus 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.5
Different species of the genus Pouteria have been used in folk medicine for the treatment of inflammation, fever, ulcers, diabetes, and diarrhea. We analyzed the phytochemical profile of the hydroethanolic extract from Pouteria ramiflora leaves by electrospray ionization ion trap tandem mass spectrometry and high-performance liquid chromatography-diode array detection, and examined whether it alone and in combination with cisplatin interfered with cell proliferation and death processes in HepG2 (human hepatocellular carcinoma) and FGH (human gingival fibroblasts) cells. Five compounds were identified in the extract: gallic acid, myricetin-3-O-α-l-arabinopyranoside, quercetin-3-O-β-d-galactopyranoside, myricetin-3-O-α-l-rhamnopyranoside, and myricetin-3-O-β-d-galactopyranoside. The extract was cytotoxic to both cell lines by inducing apoptotic cell death and acted in synergy with cisplatin; such effect was stronger in HepG2 cells than in FGH cells, demonstrating some selectivity to tumor cells. In HepG2 cells, the extract exerted antiproliferative effect mediated by induction of cell cycle arrest at the S and G2/M phases. Association of the extract with cisplatin enhanced the latter's antiproliferative effect, arrested the cell cycle at the S phase by CDK2 modulation, and reduced the number of anti-cyclin D1-stained HepG2 cells. Simultaneous treatment with the extract and cisplatin increased the latter's cytotoxicity, apoptotic cell death, and BAX expression in HepG2 cells. Altogether, the results reported herein indicate that P. ramiflora extract is a possible adjuvant to cancer therapy, which can circumvent the cisplatin-mediated resistance mechanisms in cancer cells.
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Walclecio de Moraes Lira,Fabio Vieira dos Santos,Miriam Sannomiya,Clenilson Martins Rodrigues,Wagner Vilegas,Eliana Aparecida Varanda 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian “cerrado” (tropical Americansavanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceaefamily, and it is commonly known as “murici.” Considering the popular use of B. basilobaderivatives and the lack of phar-macological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) andchloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella ty-phimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and in-direct mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B1, benzo[a]pyrene,and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level(89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B1. Phytochemical analysis of theextracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (. )-catechin, quercetin-3-O-.-L-arabinopyra-noside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2.-O-galloyl)-.-D-galactopyranoside, andquercetin-3-O-(2.-O-galloyl)-.-L-arabinopyranoside.
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