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Recent Progress in Triple Negative Breast Cancer Research
Mouh, Fatima Zahra,El Mzibri, Mohammed,Slaoui, Meriem,Amrani, Mariam Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Triple-negative breast cancer (TNBC) is defined as a type of breast carcinoma that is negative for expression of oestrogene and progesterone hormone receptors (ER, PR) and HER2. This form of breast cancer is marked by its aggressiveness, low survival rate and lack of specific therapies. Recently, important molecular characteristics of TNBC have been highlighted and led to the identification of some biomarkers that could be used in diagnosis, as therapeutic targets or to assess the prognosis. In this review, we summarize recent progress in TNBC research focusing on the genetic and epigenetic alterations of TNBC and the potential use of these biomarkers in the targeted therapy for better management of TNBC.
Breast Cancer in Morocco: A Literature Review
Slaoui, Meriem,Razine, Rachid,Ibrahimi, Azeddine,Attaleb, Mohammed,El Mzibri, Mohammed,Amrani, Mariam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
In Morocco, breast cancer is the most prevalent cancer in women and a major public health problem. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. It is therefore interesting to establish the genetic and molecular profile of Moroccan patients with breast cancer. In this paper, we will highlight some pertinent hypotheses that may enhance breast cancer care in Moroccan patients. This review will give a precise description of breast cancer in Morocco and propose some new markers for detection and prediction of breast cancer prognosis.
( Fathiah Zakham ),( Imane Chaoui ),( Driss Messaoudi ),( Mustapha Ennaji ),( Mohammed Abid ),( Mohammed El Mzibri ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Tuberculosis (TB) remains one of the most prevalent infectious diseases worldwide especially in developing countries, where the highest burden of TB is found. This is further exemplifi ed by the high mortality and morbidity due to this disease. In this context, the emergence of multi drug resistant TB and extremely drug resistant TB cases had worsened the situation. Indeed, the rapid diagnosis of MDR TB is a critical issue for TB management. This study is an attempt to establish a rapid diagnosis of MDR TB by sequencing the target fragments of rpoB gene which linked to resistance against Rifampicin and KatG gene and inhA promoter region, which are associated to resistance to Isoniazid. Methods: For this purpose, 133 sputum samples of TB patients from Morocco, where enrolled in this study. 100 samples were collected from new cases, the rest 33 were previously treated patients (drug relapse or failure, chronic) and did not respond to anti TB drugs after a suffi cient duration of treatment. All samples were subject to rpoB katG and pinhA mutations analysis by PCR and DNA sequencing. Results: Molecular analysis showed that 7 strains were isoniazid monoresistant and 17 were rifampicin monoresistant. MDR TB strains were identifi ed in 9 cases (6.8%). Among them, 8 were traditionally diagnosed as critical cases: four chronic and four drug-relapse cases. The last strain was isolated from a new case. Conclusions: The implementation of molecular approaches for direct diagnosis of MDR-TB, as a part of the routine analysis in the laboratories of health care institutions, will be of great benefi t to adapt treatment regimens, limit the dissemination of MDR-TB strains and limit the emergence of XDR-MTB strain for better management of TB in Morocco.