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신송엽,하종명,하배진,Munekata Eisuke ( Song Yub Shin,Jong Myung Ha,Bae Jin Ha,Munekata Eisuke ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.8
Neurokinin A (NKA) is neuropeptide belong to mammalian tachykinin family. To investigate the difference in biological properties between NKA and NKB from the chemical structure, the peptide derivatives of neurokinins were synthesized by solution phase method and their contractile activities were measured by contraction assay with the smooth muscle of rabbit pulmonary artery (RPA). The substituion of Ser for Phe at position 5 in NKA drastically reduced contractile activity. The replacement of Phe at 5 position in NKB with Ser showed increase in contractile activity. These results suggest that message segment including Ser at position 5 has a critical role in the biological activity of NKA.
신송엽,무네카타 에이수케 한국생화학분자생물학회 1992 생화학분자생물학회 소식 Vol.12 No.4
Three mammalian neuropeptide, SP, NKA and NKB, belong to a family of peptides known as tachykinins which share the common sequence Phe-X-Gly-Leu-Met-NH₂. These novel peptides possess a commom spectrum of biological activities including a sensory transmission in nervous system and contractions/relaxation of peripheral smooth muscles. This review will describe recent knowledges and trends on the biological activity, biosynthesis. release, distribution. receptor and antagonist of these tachykinin peptides.
Neurokinin군 펩티드유사체들의 모르모트 기관 평활근 수축활성
신송엽,하종명,하배진,장태식,강신원,무나카타 에이스케,Shin, Song-Yub,Ha, Jong-Myung,Ha, Bae-Jin,Jang, Tae-Sik,Kang, Shin-Won,Munekata, Eisuke 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.5
Substance P(SP), Neurokinin A(NKA) 및 Neurokinin B(NKB)는 포유류 유래의 신경펩티드(neuropeptide)로서 Neurokinin군으로 분류되며, Tachykinin족에 속한다. SP, NKA 및 NKB의 생물활성의 차이를 화학구조의 면에서 해명하기 위하여 Neurokinin군 펩티드들의 아미노산 배열을 서로 바꾼 유사체들을 Boc-HF에 의한 고상법에 의하여 화학합성하고, 이 펩티드들의 생물활성을 모르모트 기관(Guinea Pig Trachea : GPT)의 평활근에 대한 근육수축활성을 지표로하여 측정하였다. 본 연구에서는, GPT에 대한 Neurokinin군 펩티드들의 평활근의 수축활성은 카르복실 말단측의 7개의 아미노산이 필수적임을 확인하였다. 또한, 제4위의 아스파르트산, 제7위의 발린이 활성발현에 중요하며, NKA와 NKB의 생물활성의 차이는 제5위의 아미노산(NKA; Ser, NKB; Phe)의 구조적인 차이에 의존함이 시사되었다. Neurokinin peptides (Substance P; SP, Neurokinin A; NKA and Neurokinin B; NKB) are a neuropeptide belong to the mammalian tachykinin family. To elucidate the difference in biological properties among neurokinin peptides from chemical structure, the peptide derivatives of neurokinins were synthesized by the solution and solid-phase method and their contractile activities were measured by contraction assay with the smooth muscle of guinea pig trachea (GPT). This study demonstrated that the C-terminal heptapeptide containing two amino acid residues, $Asp^4$ and $Val^7$, is indispensible for contracting activity in GPT. Further, structureactivity studies indicate that the amino acid residues (Ser and Phe) at position 5 from N-terminus play an important role in showing the difference of biological actvity between NKA and NKB in GPT assay.
Neurokinin 군 펩티드유사체들의 모르모트 기관 평활근 수축활성
신송엽,하종명,하배진,장태식,강신원,종상 영보 ( Song Yub Shin,Jong Myung Ha,Bae Jin Ha,Tae Sik Jang,Shin Won Kang,Eisuke Munekata ) 생화학분자생물학회 1994 BMB Reports Vol.27 No.5
Neurokinin peptides (Substance P; SP, Neurokinin A; NKA and Neurokinin B; NKB) are a neuropeptide belong to the mammalian tachykinin family. To elucidate the difference in biological properties among neurokinin peptides from chemical structure, the peptide derivatives of neurokinins were synthesized by the solution and solid-phase method and their contractile activities were measured by contraction assay with the smooth muscle of guinea pig trachea (GPT). This study demonstrated that the C-terminal heptapeptide containing two amino acid residues, Asp⁴ and Val^7, is indispensible for contracting activity in GPT. Further, structureactivity studies indicate that the amino acid residues (Ser and Phe) at position 5 from N-terminus play an important role in showing the difference of biological activity between NKA and NKB in GPT assay.