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Nehal Salahuddin,Ebtisam Mohamed Ibrahim,Maged El Kemary 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
The development of a facile method for preparing electrospun artesunate-loaded inorganic/organic compositenanofiber drug delivery systems will significantly enhance the therapeutic applications of artesunate as a novel anticancermedication. Herein, artesunate- loaded citrate-functionalized hydroxyapatite nanorods (ART@Cit-HAp NRs) were prepared,and then encapsulated into PLA nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) via the electrospinningmethod. The produced Cit-HAp NRs, ART@Cit-HAp NRs and ART@Cit-HAp NRs/PLA composite nanofibers werecharacterized using a variety of comprehensive techniques. Electrospun PLA nanofibers have a smooth surface and ahomogeneous diameter without any grains on the surface. The as-prepared citrate functionalized hydroxyapatite nanorodsshowed the high drug-loading efficiency of ~92 %. The mechanism of pseudo-second-order adsorption is the most prominentmodel for ART adsorption on Cit-HAp NRs. The in vitro ART release from the composite nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) was investigated and compared to ART@Cit-HAp NRs under different pH conditions. The ARTreleased from the ART@Cit-HAp NRs/PLA composite nanofibers in a sustained, slow rate was in contrast to Cit-HAp NRsand dependent on the pH of the medium. The in vitro antitumor activity of nanoformulations were evaluated on two coloncancer (CaCo-2 and HCT 116) cell lines. The findings revealed that ART@Cit-HAp NRs/PLA composite nanofibersdemonstrated higher anti-proliferating activity compared to free ART, and the pH-triggered release of ART@Cit-HAp NRs/PLA composite nanofibers are interesting prospects for colon cancer treatment.