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- 저자 : E. Sulaiman (검색결과 5 건)
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E. Sulaiman,T. Kosaka,N. Matsui 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
Hybrid excitation flux switching synchronous machine (HEFSSM) has several attractive features compared to interior permanent magnet synchronous machines (IPMSM) conventionally employed in hybrid electric vehicles (HEV). Among various types of HEFSSM, the machine with both permanent magnet (PM) and field excitation coil (FEC) on the stator has the advantages of robust rotor structure together with variable flux control capabilities that make this machine becoming more attractive to apply for high-speed motor drive systems. This paper presents an investigation into the design possibility and parameter optimization study of 12Slot-10Pole HEFSSM for traction drives in HEV. The research target is to design a machine with reduced amount of rare-earth magnet, a maximum torque of 210Nm, a maximum power of more than 123㎾, and a maximum power density of more than 3.5㎾/㎏. Extensions in speed and torque ranges are chosen for optimization aims. The deterministic design approach is used to treat ten design parameters in an effort to achieve the target performances. As a result, the designed HEFSSM with 0.4㎏ PM is able to get much higher power density compared to existing IPMSM installed on a commercial SUV-HEV.
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Sulaiman, Rania S.,Park, Bomina,Sheik Pran Babu, Sardar Pasha,Si, Yubing,Kharwadkar, Rakshin,Mitter, Sayak K.,Lee, Bit,Sun, Wei,Qi, Xiaoping,Boulton, Michael E.,Meroueh, Samy O.,Fei, Xiang,Seo, Seung- American Chemical Society 2018 ACS CHEMICAL BIOLOGY Vol.13 No.1
<P>The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling. There are currently no FDA approved small molecules for treating these blinding eye diseases. Therefore, therapeutic agents with novel mechanisms are critical to complement or combine with existing approaches. Here, we identified soluble epoxide hydrolase (sEH), a key enzyme for epoxy fatty acid metabolism, as a target of an antiangiogenic homoisoflavonoid, SH-11037. SH-11037 inhibits sEH <I>in vitro</I> and <I>in vivo</I> and docks to the substrate binding cleft in the sEH hydrolase domain. sEH levels and activity are up-regulated in the eyes of a choroidal neovascularization (CNV) mouse model. sEH is overexpressed in human wet AMD eyes, suggesting that sEH is relevant to neovascularization. Known sEH inhibitors delivered intraocularly suppressed CNV. Thus, by dissecting a bioactive compound’s mechanism, we identified a new chemotype for sEH inhibition and characterized sEH as a target for blocking the CNV that underlies wet AMD.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2018/acbcct.2018.13.issue-1/acschembio.7b00854/production/images/medium/cb-2017-00854f_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb7b00854'>ACS Electronic Supporting Info</A></P>
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M. Z. Ahmad,E. Sulaiman,T. Kosaka 한국자기학회 2015 Journal of Magnetics Vol.20 No.3
In recent years, flux switching machines (FSMs) have been an attractive research topic owing to their tremendous advantages of robust rotor structure, high torque, and high power capability suitable for intensive applications. However, most of the investigations are focusing on the inner-rotor structure, which is incongruous for direct drive applications. In this study, high torque and power densities of a new 12S-14P outer-rotor permanent magnet (PM) FSM with a DC excitation coil was investigated based on two-dimensional finite element analysis for in-wheel direct drive electric vehicle (EV). Based on some design restrictions and specifications, design refinements were conducted on the original design machine by using the deterministic optimization approach. With only 1.0 kg PM, the final design machine achieved the maximum torque and power densities of 12.4 Nm/kg and 5.93 kW/kg, respectively, slightly better than the inner-rotor HEFSM and interior PM synchronous machine design for EV.
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Li, Feng,Zhang, Jingwen,Arfuso, Frank,Chinnathambi, Arunachalam,Zayed, M E,Alharbi, Sulaiman Ali,Kumar, Alan Prem,Ahn, Kwang Seok,Sethi, Gautam Springer-Verlag 2015 Archives of toxicology Vol.89 No.5
<P>The transcription factor nuclear factor kappa B (NF-kappa B) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-kappa B family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-kappa B pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-kappa B signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.</P>
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