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- 저자 : E. Apostolidis (검색결과 1 건)
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권영인,E. Apostolidis,Y.-C. Kim,K. Shetty 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Levels of obesity-linked noninsulin-dependent diabetes mellitus (NIDDM) and hypertension are highest amongindigenous communities in North America. This is linked to changes in dietary pattern towards high calorie foods such assugar, refined grain flour, and sweetened beverages. Therefore, a return to traditional dietary patterns may help to reduce thesedisease problems because of better balance of calories and beneficial nutrients. Further protective non-nutrient phenolic phy-tochemicals against NIDDM and hypertension are potentially high in these foods but less understood. In this study antidia-betic- and antihypertension-relevant potentials of phenolic phytochemicals were confirmed in select important traditional plantfoods of indigenous communities such as pumpkin, beans, and maize using in vitro enzyme assays for .-glucosidase, .-amy-lase, and angiotensin I-converting enzyme (ACE) inhibitory activities. In vitroinhibitory activities of these enzymes providea strong biochemical rationale for further in vivostudies and dietary management strategy for NIDDM through the control ofglucose absorption and reduction of associated hypertension. These enzyme inhibitory activities were further compared to to-tal soluble phenolic content and antioxidant activity of the above-targeted plant foods. Pumpkin showed the best overall po-tential. Among the varieties of pumpkin extracts P5 (round orange) and P6 (spotted orange green) had high content of totalphenolics and moderate antioxidant activity coupled to moderate to high .-glucosidase and ACE inhibitory activities. There-fore this phenolic antioxidant-enriched dietary strategy using specific traditional plant food combinations can generate a wholefood profile that has the potential to reduce hyperglycemia-induced pathogenesis and also associated complications linked tocellular oxidation stress and hypertension.
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