http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Doré (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Millea, M.,Doré,, O.,Dudley, J.,Holder, G.,Knox, L.,Shaw, L.,Song, Y.-S.,Zahn, O. IOP Publishing 2012 The Astrophysical journal Vol.746 No.1
<P>Using the latest physical modeling and constrained by the most recent data, we develop a phenomenological parameterized model of the contributions to intensity and polarization maps at millimeter wavelengths from external galaxies and Sunyaev-Zeldovich effects. We find such modeling to be necessary for estimation of cosmological parameters from Planck data. For example, ignoring the clustering of the infrared background would result in a bias in ns of 7s in the context of an eight-parameter cosmological model. We show that the simultaneous marginalization over a full foreground model can eliminate such biases, while increasing the statistical uncertainty in cosmological parameters by less than 20%. The small increases in uncertainty can be significantly reduced with the inclusion of higher-resolution ground-based data. The multi-frequency analysis we employ involves modeling 46 total power spectra and marginalization over 17 foreground parameters. We show that we can also reduce the data to a best estimate of the cosmic microwave background power spectra, with just two principal components (with constrained amplitudes) describing residual foreground contamination.</P>
-
Liu, Lei,Vollmer, Mary K.,Ahmad, Abdullah S.,Fernandez, Victoria M.,Kim, Hocheol,Doré,, Sylvain PERGAMON PRESS 2019 FREE RADICAL BIOLOGY AND MEDICINE Vol.131 No.-
<P><B>Abstract</B></P> <P>The transcriptional factor Nrf2, a master regulator of oxidative stress and inflammation that are tightly linked to the development and progression of cerebral ischemia pathology, plays a vital role in inducing the endogenous neuroprotective process. Here, hypoxic-ischemia (HI) was performed in adult Nrf2 knockout and wildtype mice that were orally pretreated either with standardized Korean red ginseng extract (Ginseng) or dimethyl fumarate (DMF), two candidate Nrf2 inducers, to determine whether the putative protection was through an Nrf2-dependent mechanism involving the attenuation of reactive gliosis. Results show that Nrf2 target cytoprotective genes were distinctly elevated following HI. Pretreatment with Ginseng or DMF elicited robust neuroprotection against the deterioration of acute cerebral ischemia damage in an Nrf2-dependent manner as revealed by the reductions of neurological deficits score, infarct volume and brain edema, as well as enhanced expression levels of Nrf2 target antioxidant proteins and anti-inflammation mediators. In both ischemic striatum and cortex, the dynamic pattern of attenuated reactive gliosis in astrocytes and microglia, including affected astrocytic dysfunction in glutamate metabolism and water homeostasis, correlated well with the Nrf2-dependent neuroprotection by Ginseng or DMF. Furthermore, such neuroprotective benefits extended to the late phase of ischemic brain damage after HI, as evidenced by improvements in neurobehavioral outcomes, infarct volume and brain edema. Overall, pretreatment with Ginseng or DMF identically attenuates reactive gliosis and confers long-lasting neuroprotective efficacy against ischemic brain damage through an Nrf2-dependent mechanism. This study also provides new insight into the profitable contribution of reactive gliosis in the Nrf2-dependent neuroprotection in acute brain injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ginseng/DMF reduces the exacerbation in infarction, edema and neurological deficits. </LI> <LI> Ginseng/DMF attenuates Nrf2-dependent reactive gliosis in microglia and astrocyte. </LI> <LI> Ginseng/DMF likely alleviates Nrf2-dependent glutamate clearance and water transport. </LI> <LI> Ginseng/DMF decreases the oxidative and inflammatory insults by an Nrf2 mechanism. </LI> <LI> Ginseng/DMF displays a long-lasting efficacy, but lacks under Nrf2 deficiency. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
-
Bu, Youngmin,Kwon, Sungeun,Kim, Yun Tai,Kim, Mi-Yeon,Choi, Hoyoung,Kim, Jae Goo,Jamarkattel-Pandit, Nirmala,Doré,, Sylvain,Kim, Sung-Hoon,Kim, Hocheol John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.8
<P>HT008-1 is one of the prescriptions used in Traditional Korean Medicine for the treatment of mental and physical weakness. It is composed of Panax ginseng, Acanthopanax senticosus, Angelica sinensis and Scutellaria baicalensis, which have been reported to have various pharmacological effects on the central nervous system. The study investigated whether HT008-1 has neuroprotective effects in a focal cerebral ischemia rat model. Stroke was induced in rats by 2 h of middle cerebral artery occlusion (MCAo) followed by 22 h of reperfusion. HT008-1 (30, 100 and 300 mg/kg) and the component herbs (300 mg/kg) were administered orally twice at 0 and 2 h after ischemia. Oral administration of 300 mg/kg HT008-1 reduced brain infarction by 45.7%, prolonged the latency time by 24.8% in the rotarod test, and enhanced the score by 17.0% in the balance beam test. Only P. ginseng and S. baicalensis showed protective effects, and HT008-1 showed a greater effect than its component herbs. HT008-1 down-regulated the COX-2 and OX-42 expression in the penumbra region. In conclusion, the results show that HT008-1 may be effective in a rat stroke model by an antiinflammatory mechanism and may improve sensory-motor function by reducing damage in the cortex and caudoputamen. Copyright © 2010 John Wiley & Sons, Ltd.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
