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        Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration

        Zhao Jing,Lu Feng,Dong Ziqing 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.3

        Background: Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue engineering (ATE) provides a promising way to solve this problem. Methods: This review summarizes the current ATE strategies for soft tissue reconstruction, and introduces potential construction methods for ATE. Results: Scaffold-based and scaffold-free strategies are the two main approaches in ATE. Although several of these methods have been effective clinically, both scaffold-based and scaffold-free strategies have limitations. The third strategy is a synergistic tissue engineering strategy and combines the advantages of scaffold-based and scaffold-free strategies. Conclusion: Personalized construction, stable survival of reconstructed tissues and functional recovery of organs are future goals of building tissue-engineered fat for ATE. Background: Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue engineering (ATE) provides a promising way to solve this problem. Methods: This review summarizes the current ATE strategies for soft tissue reconstruction, and introduces potential construction methods for ATE. Results: Scaffold-based and scaffold-free strategies are the two main approaches in ATE. Although several of these methods have been effective clinically, both scaffold-based and scaffold-free strategies have limitations. The third strategy is a synergistic tissue engineering strategy and combines the advantages of scaffold-based and scaffold-free strategies. Conclusion: Personalized construction, stable survival of reconstructed tissues and functional recovery of organs are future goals of building tissue-engineered fat for ATE.

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