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Can Electroacupuncture Be Useful in Opioid-Induced Hyperalgesia? A Case Report
Di Carlo Marco,D’Addario Antonio,Salaffi Fausto 사단법인약침학회 2023 Journal of Acupuncture & Meridian Studies Vol.16 No.5
Opioid-induced hyperalgesia (OIH) is characterized by a paradoxical increase in pain sensitivity following opioid exposure. Although animal models indicate that electroacupuncture (EA) is effective against pain sensitization, there are no reports of its clinical application in OIH treatment. This case report involves an adult patient with osteomalacia complicated by multiple vertebral fragility fractures. The patient developed OIH following the use of oxycodone to treat severe disabling lower back pain that was refractory to nonsteroidal anti-inflammatory drugs. After hospitalization and treatment with low EA-frequency (2-10 Hz) sessions, the patient exhibited significant pain reduction and functional recovery after the first session, which was accompanied by steady progressive improvement as the treatment continued. This case report illustrates the clinical efficacy of EA in OIH treatment and indicates that EA, which has multiple modes of action on the neurobiology of chronic pain, has potential applications in the management of complex and difficult-to-manage conditions, such as OIH.
Lee, Jin-Wook,Dai, Zhenghong,Lee, Changsoo,Lee, Hyuck Mo,Han, Tae-Hee,De Marco, Nicholas,Lin, Oliver,Choi, Christopher S.,Dunn, Bruce,Koh, Jaekyung,Di Carlo, Dino,Ko, Jeong Hoon,Maynard, Heather D.,Ya American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.20
<P>The Lewis acid-base adduct approach has been widely used to form uniform perovskite films, which has provided a methodological base for the development of high-performance perovskite solar cells. However, its incompatibility with formamidinium (FA)-based perovskites has impeded further enhancement of photovoltaic performance and stability. Here, we report an efficient and reproducible method to fabricate highly uniform FAPbI<SUB>3</SUB> films via the adduct approach. Replacement of the typical Lewis base dimethyl sulfoxide (DMSO) with <I>N</I>-methyl-2-pyrrolidone (NMP) enabled the formation of a stable intermediate adduct phase, which can be converted into a uniform and pinhole-free FAPbI<SUB>3</SUB> film. Infrared and computational analyses revealed a stronger interaction between NMP with the FA cation than DMSO, which facilitates the formation of a stable FAI·PbI<SUB>2</SUB>·NMP adduct. On the basis of the molecular interactions with different Lewis bases, we proposed criteria for selecting the Lewis bases. Owed to the high film quality, perovskite solar cells with the highest PCE over 20% (stabilized PCE of 19.34%) and average PCE of 18.83 ± 0.73% were demonstrated.</P> [FIG OMISSION]</BR>