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Phytochemistry and pharmacological activity of the genus artemisia
Dheeraj Bisht,Deepak Kumar,Dharmendra Kumar,Kamal Dua,Dinesh Kumar Chellappan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.5
Artemisia and its allied species have beenemployed for conventional medicine in the Northern temperateregions of North America, Europe, and Asia for thetreatments of digestive problems, morning sickness, irregularmenstrual cycle, typhoid, epilepsy, renal problems, bronchitismalaria, etc. The multidisciplinary use of artemisiaspecies has various other health benefi ts that are related toits traditional and modern pharmaceutical perspectives. Themain objective of this review is to evaluate the traditional,modern, biological as well as pharmacological use of theessential oil and herbal extracts of Artemisia nilagirica,Artemisia parvifl ora, and other allied species of Artemisia. It also discusses the botanical circulation and its phytochemicalconstituents viz disaccharides, polysaccharides,glycosides, saponins, terpenoids, flavonoids, and carotenoids. The plants have diff erent biological importance likeantiparasitic, antimalarial, antihyperlipidemic, antiasthmatic, antiepileptic, antitubercular, antihypertensive, antidiabetic,anxiolytic, antiemetic, antidepressant, anticancer, hepatoprotective,gastroprotective, insecticidal, antiviral activities, andalso against COVID-19. Toxicological studies showed thatthe plants at a low dose and short duration are non or lowtoxic. In contrast, a high dose at 3 g/kg and for a longer durationcan cause toxicity like rapid respiration, neurotoxicity,reproductive toxicity , etc. However, further in-depth studiesare needed to determine the medicinal uses, clinical effi cacyand safety are crucial next steps.