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Expression of Thymosin α1-thymopentin Fusion Peptide in Pichia pastoris and its Characterization
Demin Gao,Xulong Zhang,Jian Zhang,Jichao Cao,Fengshan Wang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin α1-thymopentin (Tα1-TP5) gene was synthesized and cloned into vector pGAPZαA. Tα1-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of Tα1-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of Tα1-TP5 fusion peptide is 140 ±14 min, which is longer than that of TP5 (5.6±0.7 min) and Tα1 (127±11 min). The in vitro activity assay presented that Tα1-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both Tα1 and TP5. Our findings suggest that Tα1-TP5 fusion peptide might be a potential therapeutic agent.
Gao, Demin,Zhang, Xulong,Zhang, Jian,Cao, Jichao,Wang, Fengshan 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin ${\alpha}1$-thymopentin ($T{\alpha}1$-TP5) gene was synthesized and cloned into vector $pGAPZ{\alpha}A$. $T{\alpha}1$-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of $T{\alpha}1$-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of $T{\alpha}1$-TP5 fusion peptide is $140{\pm}14\;min$, which is longer than that of TP5 ($5.6{\pm}0.7\;min$) and $T{\alpha}1$ ($127{\pm}11\;min$). The in vitro activity assay presented that $T{\alpha}1$-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both $T{\alpha}1$ and TP5. Our findings suggest that $T{\alpha}1$-TP5 fusion peptide might be a potential therapeutic agent.
An Efficient Multiple-Copy Routing in Intermittently Connected Mobile Networks
Fuquan Zhang,Inwhee Joe,Demin Gao,Yunfei Liu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.5
PRoPHET (probability routing protocol using history of encounters and transitivity) reduces the invalid copy of message, so that effectively reduce the network overhead and the traffic load in the network. However, the calculation of probability in Prophet does not consider the network conditions. In this paper, we improve the performance of PRoPHET protocol by taking into account connection status to calculate nodes’ encountering probability. The performance of the proposed protocol was analyzed in terms of delivery probability, average delay, and overhead ratio. Numerical results show that the proposed protocol can improve the performance to some extend.
Changxin Liu,Jian Gao,Demin Xu 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5
This paper studies the tracking problem of nonholonomic wheeled robots subject to control input constraints. In order to take optimality considerations into account while designing saturated tracking controllers, aLyapunov-based predictive tracking controller is developed, in which the contractive constraint is characterized bya backup global saturated tracking controller. Theoretical results on ensuring global feasibility and closed-loop stabilityof the controller are provided. In addition, the proposed methodology admits suboptimal solutions. Finally,numerical simulations are performed to verify the effectiveness of the proposed control strategy.
Measurement and Application of Link Reliability for Wireless Mobile Networks
Fuquan Zhang,Inwhee Joe,Demin Gao,Yunfei Liu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.6
Radio channel characteristics of mobile nodes are quite different compared with the traditional stationary base station to mobile radio channel. Wireless link reliability estimation is necessary for self-organization of wireless mobile multihop networks. In this paper, we measure narrowband path loss measurements in a typical mobile-to-mobile radio environment. For application, we proposed a method to incorporate link reliability into path reliability evaluation and selection for multipath routing in wireless mobile networks. Simulations show that the proposed method has better performance.
A Survey on Organization and Positioning of Nodes in Wireless Sensor Network
Xinyi Tan,Fuquan Zhang,MengMeng Shi,Demin Gao,Yunfei Liu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.11
Wireless sensor network has a rapid growth in both science research and commercial development as well as been widely used in a variety of realms. Facing different kinds of challenging issues of WSNs, the deployment of nodes stands out for it has a critical influence on area or target coverage, network connectivity, network lifetime, etc. This paper explores classifications of node and deployment strategies from different angles, weighing their pros and cons and analyzing its impacts on the performance of a WSN.
A Way of Candidate Set Selection for Epidemic Routing in Delay Tolerate Networks
Fuquan Zhang,Kaiqi Chen,Inwhee Joe,Demin Gao,Yunfei Liu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.10
The radio propagation effect of fading or shadowing between mobile nodes has not been well considered in contact rate. One way to incorporate interference into contact rate is multiplied by probability that the infected node copies the message to the susceptible node during a contact in epidemic routing. In this paper, we develop a model to incorporate the wireless link reliability into contact rate. For application, we proposed a scheme for epidemical delay tolerate network with considering the effects based on the model. Simulation shows that proposed scheme has better performance.