SOME RESULTS ON CONDITIONALLY UNIFORMLY STRONG MIXING SEQUENCES OF RANDOM VARIABLES

De-Mei Yuan,Xue-Mei Hu,Bao Tao 대한수학회 2014 대한수학회지 Vol.51 No.3

From the ordinary notion of uniformly strong mixing for a se- quence of random variables, a new concept called conditionally uniformly strong mixing is proposed and the relation between uniformly strong mix- ing and conditionally uniformly strong mixing is answered by examples, that is, uniformly strong mixing neither implies nor is implied by condi- tionally uniformly strong mixing. A couple of equivalent definitions and some of basic properties of conditionally uniformly strong mixing ran- dom variables are derived, and several conditional covariance inequalities are obtained. By means of these properties and conditional covariance inequalities, a conditional central limit theorem stated in terms of condi- tional characteristic functions is established, which is a conditional version of the earlier result under the non-conditional case.

Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi

Hu Xi-Jiang,Su Mei-Ru,Cao Bao-Wei,Ou Fa-Bang,Yin Rui-Xing,Luo An-De 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-

Background The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. This study aimed to explore the association between the MTHFR rs1801133 SNP and serum Hcy levels of Zhuang hypertensive patients in the central region of Guangxi. Methods A total of 606 Zhuang inpatients with essential hypertension were recruited in our hospital from August 2016 to December 2018. The patients were divided into H-type hypertension (Hcy > 10 μmol/L, n = 528) and non–Htype hypertension (Hcy ≤ 10 μmol/L, n = 78) groups. At the same time, an age- and sex-matched group of 379 subjects with normal physical examination in our hospital were selected as the control group. Blood biochemical measurements and genotyping of the MTHFR rs1801133 SNP were performed. Results The prevalence of H-type hypertension was 87.13%. The levels of serum Hcy in patients with hypertension were higher than those in control group (14.20 ± 5.78 μmol/L vs. 11.97 ± 5.39 μmol/L, P < 0.001), especially in patients with H-type hypertension (15.08 ± 5.65 μmol/L, P < 0.001). The frequencies of TT genotype (22.73%) and T allele (46.21%) in patients with H-type hypertension were significantly higher than those in control group (11.35% and 30.47%, respectively) and non–H-type hypertension group (10.26% and 28.85%, respectively; P < 0.001 for all). Multivariate linear regression analysis showed that serum Hcy levels were significantly correlated with creatinine, lowdensity lipoprotein cholesterol, endogenous creatinine clearance rate, and the MTHFR rs1801133 genotypes in control group, while serum Hcy levels were significantly correlated with creatinine, triglyceride, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, glycosylated hemoglobin, and the MTHFR rs1801133 genotypes in H-type hypertension group (P < 0.05–0.001). Serum Hcy levels in the T allele carriers were higher than those in the T allele noncarriers in both H-type hypertension and control groups. Conclusions There was closely related between the MTHFR rs1801133 SNP and serum Hcy levels in Zhuang patients with H-type hypertension in the central region of Guangxi. The MTHFR SNP may be an important reason for the increase of serum Hcy levels in Zhuang patients with H-type hypertension in this region.

SOME RESULTS ON CONDITIONALLY UNIFORMLY STRONG MIXING SEQUENCES OF RANDOM VARIABLES

Yuan, De-Mei,Hu, Xue-Mei,Tao, Bao Korean Mathematical Society 2014 대한수학회지 Vol.51 No.3

From the ordinary notion of uniformly strong mixing for a sequence of random variables, a new concept called conditionally uniformly strong mixing is proposed and the relation between uniformly strong mixing and conditionally uniformly strong mixing is answered by examples, that is, uniformly strong mixing neither implies nor is implied by conditionally uniformly strong mixing. A couple of equivalent definitions and some of basic properties of conditionally uniformly strong mixing random variables are derived, and several conditional covariance inequalities are obtained. By means of these properties and conditional covariance inequalities, a conditional central limit theorem stated in terms of conditional characteristic functions is established, which is a conditional version of the earlier result under the non-conditional case.

The differentiation of human multipotent adult progenitor cells into hepatocyte-like cells induced by coculture with human hepatocyte line L02

Ning Mu,Hong-Bao Liu,Qiu-Hong Meng,De-Wei Du,Yi Jiang,Huan-Zhang Hu 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.1

Purpose: The aim of this study was to establish an in vitro method to purify human multipotent adult progenitor cells (hMAPCs) and assess their possible differentiation into hepatocytes by coculture with human hepatocyte line L02. Methods: hMAPCs were isolated by magnetic activated cell sorting (MACS) depletion selection using CD45 and GlyA microbeads. After indirect or direct coculture of hMAPCs and human hepatocyte line L02, the expression of albumin (ALB), alpha-fetoprotein (AFP), cytokeratin (CK) 18, and CK19 by hMAPCs was detected by immunocytochemistry. Results: With the MACS method, (5?10) × 10⁴/mL hMAPCs could be separated from 1 × 10?/mL bone marrow mononuclear cells. The purity of CD45-/GlyA- cells separated from bone marrow adherent cells was more than 98%, as determined by flow cytometry. In the coculture without cell-to-cell contact, hMAPCs expressed high AFP on day 1, and then tapered daily to low expression on day 7; ALB expression reached its peak on day 5, and remained high on day 7; CK18 was initially expressed on day 5 and was higher on day 7; CK19 was negative in all assays. In the coculture with cell-to-cell contact, ALB and CK18 were expressed by most cells while AFP appeared in only a few on day 5. Conclusion: hMAPCs were induced to differentiate into mature hepatocyte-like cells by coculture with a hepatocyte cell line, either with or without cell-to-cell contact, but the former seemed more effective.

NUMERICAL SIMULATION AND PREDICTION OF NEGATIVE STORM SURGE IN THE YANGTZE RIVER ESTUARY

Zeng Hao Qin,Yi Hong Duan,De Bao Hu,Mao Xing Gong 한국해안해양공학회 1999 학술강연회 발표논문초록집 Vol.1 No.1

An attempt is made by using both statistical model and multi-layer simplified ECOM-Si model with temperature and salinity effects neglected to investigate numerically the negative storm surge (SS) in the Yangtze River estuary. An operational system for predicting the negative SS are constructed in conjunction of ECOM-Si model with the operational limited-area fine-mesh numerical weather prediction (NWP) model developed by the Shanghai Typhoon Institute(STI).To test the reliability of ECOM-Si model and to understand the computational feature of the model in simulating sea surface elevation, both semi-diurnal tide computation at the river mouth tidal station and numerical SS simulations under the action of idealized easterly and westerly winds are completed. Based on these experiments, a series of negative SS simulations induced by the cold wave, tropical and extratropical cyclones are carried out respectively, in which the objective analysis data of atmospheric forcings on the sea surface are offered by STI NWP model. Case experiments show that the predicted peak negative SS are coincident with the real ones and the phase differences between them are within a acceptable limit. The system is hopeful in operational use for predicting negative SS in the Yangtze River estuary.