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Luo, Dandan,Ruan, Shichao,Liu, Aiping,Kong, Xiangdong,Lee, In-Seop,Chen, Cen Dove Medical Press 2018 International journal of nanomedicine Vol.13 No.-
<P><B>Background</B></P><P>Functionalizing biomaterial substrates with biological signals shows promise in regulating neural stem cell (NSC) behaviors through mimicking cellular microenvironment. However, diverse methods for immobilizing biological molecules yields promising results but with many problems. Biomimetic apatite is an excellent carrier due to its non-toxicity, good biocompatibility, biodegradability, and favorable affinity to plenty of molecules. Therefore, it may provide a promising alternative in regulating NSC behaviors.</P><P><B>Methods</B></P><P>Biomimetic apatite immobilized with the extracellular protein – laminin (LN) was prepared through coprecipitation process in modified Dulbecco’s phosphate-buffered saline (DPBS) containing LN. The amount of coprecipitated LN and their release kinetics were examined. The adhesion and proliferation behaviors of NSC on biomimetic apatite immobilized with LN were investigated.</P><P><B>Results</B></P><P>The coprecipitation approach provided well retention of LN within biomimetic apatite up to 28 days, and supported the adhesion and proliferation of NSCs without cytotoxicity. For long-term cultivation, NSCs formed neurosphere-like aggregates on non-functionalized biomimetic apatite. A monolayer of proliferated NSCs on biomimetic apatite with coprecipitated LN was observed and even more stable than the positive control of LN coated tissue-culture treated polystyrene (TCP).</P><P><B>Conclusion</B></P><P>The simple and reproducible method of coprecipitation suggests that biomimetic apatite is an ideal carrier to functionalize materials with biological molecules for neural-related applications.</P>
Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent
Chen, Cen,Yao, Chenxue,Yang, Jingxin,Luo, Dandan,Kong, Xiangdong,Chung, Sung-Min,Lee, In-Seop Elsevier 2017 Colloids and surfaces Biointerfaces Vol.151 No.-
<P><B>Abstract</B></P> <P>In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biomimetic apatite is formed on Co-Cr alloy as a polymer-free drug carrier. </LI> <LI> To inhibit in-stent restenosis, sirolimus is loaded within apatite in two ways. </LI> <LI> Porous and biodegradable biomimetic apatite releases of sirolimus over 40days. </LI> <LI> Integrity of biomimetic apatite is sufficient for clamping and balloon expansion. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>