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RISS 인기검색어
- 검색키워드
- 저자 : Dakshayani, K.B. (검색결과 3 건)
- 무료
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P. Subramanian,K.B. Dakshayani 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
The effect of .-ketoglutarate (.-KG) on circadian patterns of lipid peroxides and antioxidants in N-nitrosodi-ethylamine (NDEA)-induced hepatocarcinogenesis in rats has been studied. The circadian rhythm characteristics (acrophase,amplitude, and mesor) of thiobarbituric acid-reactive substances (TBARS), antioxidants, superoxide dismutase, catalase, glu-tathione peroxidase, and reduced glutathione were markedly altered in NDEA-treated rats. The delays in acrophase observedin NDEA-treated rats were brought back to near normal range by the administration of .-KG. An increase in mesor valuesof TBARS and a decrease in mesor values of antioxidants in NDEA-administered rats were reversed by .-KG administra-tion. It can be concluded that .-KG exerts its chemopreventive effect by restoring antioxidants and their circadian rhythms.
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Rao, K.V.K.,Samikkannu, T.,Dakshayani, K.B.,Zhang, X.,Sathaye, S.S.,Indap, M.A.,Nair, Madhavan P.N. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Background: Turmeric ($Curcuma$ $longa$) has been shown to possess anti-inflammatory, antioxidant and antitumor properties. However, despite the progress in research with $C.$ $longa$, there is still a big lacuna in the information on the active principles and their molecular targets. More particularly very little is known about the role of cell cycle genes $p57^{kip2}$ and Rad9 during chemoprevention by turmeric and its derivatives especially in prostate cancer cell lines. Methods: Accordingly, in this study, we have examined the antitumor effect of several extracts of $C.$ $longa$ rhizomes by successive fractionation in clonogenic assays using highly metastatic PC-3M prostate cancer cell line. Results: A mixture of isopropyl alcohol: acetone: water: chloroform: and methanol extract of $C.$ $longa$ showed significant bioactivity. Further partition of this extract showed that bioactivity resides in the dichloromethane soluble fraction. Column chromatography of this fraction showed presence of biological activity only in ethyl acetate eluted fraction. HPLC, UV-Vis and Mass spectra studies showed presence three curcuminoids in this fraction besides few unidentified components. Conclusions: From these observations it was concluded that the ethyl acetate fraction showed not only inhibition of colony forming ability of PC-3M cells but also up-regulated cell cycle genes $p57^{kip2}$ and Rad9 and further reduced the migration and invasive ability of prostate cancer cells.
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Oxidative conversion of anilines to azobenzenes with alkaline chloramine-T
Puttaswamy,Adalagere Somashekar Manjunatha,Shankarlingaiah Dakshayani,Nirmala Vaz 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2
Anilines are widely used in the manufacture of dyes, medicinals, plastics and perfumes. Anilines are readily oxidized to give products depending on reaction conditions. Conversion of anilines to azobenzene is important in organic synthesis. In the course of this research, optimum conditions for the facile oxidative conversion of anilines to azobenzenes have been established in very good yields. The kinetics of oxidation of aniline, p-methoxyaniline, p-methylaniline, p-carboxylicaniline and p-nitroaniline by chloramine-T (CAT) in NaOH medium shows identical kinetics with a first-order dependence of rate on [CAT]o, fractional-order on [Aniline]o, and an inverse-fractional order on [OH−]. Activation parameters and decomposition constants have been determined. Oxidation products were characterized by NMR spectral studies. Isokinetic temperature is 415 K indicating enthalpy as a controlling factor. The rates increased in the order: p-methoxyaniline>p-methylaniline>aniline>p-carboxylicani- line>p-nitroaniline. A Hammett linear free energy relationship is observed for the reaction with ρ=−0.52. Reaction scheme and kinetic rate law were deduced. We have developed a simple and efficient protocol for the synthesis of azobenzenes by anilines in good yields and hence we believe that this methodology will be a valuable addition to the existing methods.
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